Compound ID	Name	Phase	Molecular Mechanism	Therapeutic Group
DOM_SIM_001	Metaxalone	Launched		Muscle Spasms, Drugs for
DOM_SIM_002	6-Hydroxyhyoscyamine	Clinical	TNF-alpha Production Inhibitors	Diabetic Retinopathy, Agents for; Acute Respiratory Distress Syndrome (ARDS), Agents for; Treatment of Disorders of the Coronary Arteries and Atherosclerosis; Pulmonary Emphysema, Agents for
DOM_SIM_003	Hydroxyectoin	Launched		Inflammatory Bowel Disease, Agents for; Inflammation, Treatment of; Alzheimer's Dementia, Treatment of ; Dermatologic Drugs
DOM_SIM_004	Hydrocortisone 17-butyrate	Launched		Antipruritics; Atopic Dermatitis, Agents for; Dermatologic Drugs
DOM_SIM_005	Actarit	Launched-1994		Rheumatoid Arthritis, Treatment of
DOM_SIM_006	NG-nitro-arginine	Clinical	Nitric Oxide Synthase Inhibitors	Cardiovascular Diseases (Not Specified)
DOM_SIM_007	Nepafenac	Launched-2005	Prostaglandin G/H Synthase 2 (PTGS2; COX-2) Inhibitors	Antiinflammatory Ophthalmic Agents; Diabetic Retinopathy, Agents for; Non-Opioid Analgesics
DOM_SIM_008	Amisulpride	Launched-1986	Dopamine D2 Receptor (DRD2) Antagonists	Antipsychotic Drugs; Disorders Associated with Cancer Therapy, Treatment of; Nausea and Vomiting, Treatment of; Obsessive-Compulsive Disorder (OCD), Treatment of
DOM_SIM_009	Prulifloxacin	Launched-2002	DNA Gyrase (Bacterial) Inhibitors	Antibacterial Drugs
DOM_SIM_010	Ticagrelor	Launched-2011	P2Y12 (P2T) Receptor Antagonists	Antiplatelet Therapy; Treatment of Disorders of the Coronary Arteries and Atherosclerosis; Cardiovascular Diseases (Not Specified)
DOM_SIM_011	Clofazimina	Launched		Treatment of Protozoal Diseases; Antimycobacterial Agents; Treatment of Leprosy; Oncolytic Drugs; Treatment of Tuberculosis
DOM_SIM_012	cis-urocanic-acid			
DOM_SIM_013	L-Pyroglutamic Acid			
DOM_SIM_014	Aceneuramic acid sodium salt	Pre-Registered		Nasal Decongestants; Antitussives; Antiviral Drugs; Expectorants
DOM_SIM_015	Fluorofur	Launched-1972		Oncolytic Drugs
DOM_SIM_016	Oxiracetam	Launched-1987		Cognition Disorders, Treatment of
DOM_SIM_017	(E)-Caryophyllene	Clinical	Acetylcholinesterase (AChE) Inhibitors	Neuropathic Pain, Treatment of; Antidepressants; Antiarthritic Drugs; Antibacterial Drugs
DOM_SIM_018	Pazufloxacin	Launched	DNA Gyrase (Bacterial) Inhibitors	Antibacterial Drugs
DOM_SIM_019	(5-fluoro-3-pyridyl)methanol	Clinical		Lipoprotein Disorders, Treatment of
DOM_SIM_020	IB-1001	Launched		Neurological Genetic Disorders, Treatment of ; Multisystem Genetic Disorders, Treatment of ; Therapy of Inborn Errors of Metabolism; Cognition Disorders, Treatment of; Ear disorders, treatment of
DOM_SIM_021	Cefuroxime sodium	Launched-1977	Penicillin-Binding Protein (PBP) (Bacterial) Inhibitors	Antibiotics; Antibacterial Drugs
DOM_SIM_022	Proscillaridin	Launched		Oncolytic Drugs; Heart Failure Therapy
DOM_SIM_023	Pimonidazole hydrochloride	Phase III		Oncolytic Drugs; Diagnosis of Cancer
DOM_SIM_024	Ritanserin	Phase III	5-HT2A Receptor Antagonists	Treatment of Alcohol Dependency; Anxiolytics; Antipsychotic Drugs; Antidepressants; Glioblastoma Multiforme Therapy
DOM_SIM_025	Agomelatine	Launched-2006	5-HT2C Receptor Antagonists	Bipolar Disorder, Treatment of; Autism, Treatment of; Antidepressants
DOM_SIM_026	Capecitabine	Launched-1998	Pyrimidine Antagonists	Neurologic Cancer Therapy; Gastric Cancer Therapy; Skin Cancer Therapy; Breast Cancer Therapy; Ovarian Cancer Therapy; Digestive/Gastrointestinal Cancer Therapy; Pancreatic Cancer Therapy; Colorectal Cancer Therapy; Renal Cancer Therapy; Glioblastoma Multiforme Therapy; Solid Tumors Therapy; Liver Cancer Therapy; Head and Neck Cancer Therapy; Cancer Associated Disorders, Treatment of
DOM_SIM_027	Enalaprilat	Launched-1987	Angiotensin-I Converting Enzyme (ACE) Inhibitors	Hypertension, Treatment of
DOM_SIM_028	54189144			
DOM_SIM_029	Cinacalcet hydrochloride	Launched-2004	Calcium-Sensing Receptor (CaSR) Agonists	Prostate Cancer Therapy; Endocrine Cancer Therapy; Treatment of Hyperparathyroidism; Treatment of Hypercalcemia; Cardiovascular Diseases (Not Specified)
DOM_SIM_030	Cefixime	Launched-1987		
DOM_SIM_031	Enrofloxacin	Launched-1989	DNA Gyrase (Bacterial) Inhibitors	Antibacterial Drugs
DOM_SIM_032	Levofloxacin	Launched-1993	DNA Gyrase (Mycobacterium tuberculosis) Inhibitors	Antibacterial Ophthalmic Drugs; Antibacterial Drugs; Treatment of Tuberculosis
DOM_SIM_033	Ubenimex	Launched-1987	Drugs Targeting Inhibitor of Apoptosis Proteins (IAP)	Lung Cancer Therapy; Leukemia Therapy; Immunostimulants; Cardiovascular Diseases (Not Specified); Pulmonary Hypertension, Treatment of
DOM_SIM_034	Amfenac sodium	Launched-1985	Prostaglandin G/H Synthase 2 (PTGS2; COX-2) Inhibitors	
DOM_SIM_035	Loxoribine	Phase II	Toll-Like Receptor 7 (TLR7) Ligands	
DOM_SIM_036	9-Aminocamptothecin	Phase III	DNA Topoisomerase I Inhibitors	Lymphoma Therapy; Leukemia Therapy; Bladder Cancer Therapy ; Ovarian Cancer Therapy; Breast Cancer Therapy; Colorectal Cancer Therapy; Treatment of AIDS-Associated Disorders
DOM_SIM_037	1-MT	Clinical	Indoleamine 2,3-dioxygenase 1 (IDO1; IDO) Inhibitors	Anti-HIV Agents; Immunostimulants
DOM_SIM_038	Trandolapril	Launched-1993	Angiotensin-I Converting Enzyme (ACE) Inhibitors	Hypertension, Treatment of; Heart Failure Therapy
DOM_SIM_039	Nilotinib hydrochloride monohydrate	Launched-2007	Tyrosine-Protein Kinase ABL1 (ABL) Inhibitors	Lymphocytic Leukemia Therapy; Antiparkinsonian Drugs; Neurologic Cancer Therapy; Melanoma Therapy; Oncolytic Drugs; Alzheimer's Dementia, Treatment of ; Digestive/Gastrointestinal Cancer Therapy; Myeloid Leukemia Therapy; Colorectal Cancer Therapy; Pulmonary Hypertension, Treatment of; Head and Neck Cancer Therapy
DOM_SIM_040	Homotaurine	Discontinued	beta-Amyloid (Abeta) Aggregation Inhibitors	Hemorrhagic Stroke, Treatment of; Alzheimer's Dementia, Treatment of
DOM_SIM_041	Procysteine	Phase III	Antiinflammatory Drugs	Hepatoprotectants; Anti-HIV Agents; Acute Respiratory Distress Syndrome (ARDS), Agents for; Treatment of Disorders of the Coronary Arteries and Atherosclerosis; Amyotrophic Lateral Sclerosis, Agents for
DOM_SIM_042	Orotic acid	Launched		Cardioprotective Agents
DOM_SIM_043	Hyperin	Clinical	Lysosomal alpha-Glucosidase (GAA) Inhibitors	Non-Opioid Analgesics; Stroke, Treatment of; Vasodilators
DOM_SIM_044	Uridine triphosphate	Phase III	P2Y2 Receptor Agonists	Medical Diagnosis; Diagnosis of Cancer
DOM_SIM_045	Betamipron	Launched		
DOM_SIM_046	Eprodisate disodium	Clinical	Antiamyloidogenic Agents	Amyloidosis, Treatment of; Hematologic Agents (Miscellaneous); Type 2 Diabetes, Agents for
DOM_SIM_047	Iguratimod	Launched-2012	NF-kappaB (NFKB) Activation Inhibitors	Disease-Modifying Anti-Rheumatic Drugs; Sjogren's Syndrome, Agents for; Rheumatoid Arthritis, Treatment of; Nephritis, Agents for
DOM_SIM_048	Tolcapone	Launched-1997	Catechol-O-Methyl Transferase (COMT) Inhibitors	Psychiatric Disorders (Not Specified); Antiparkinsonian Drugs; Neurological Genetic Disorders, Treatment of ; Antipsychotic Drugs; Amyloidosis, Treatment of; Anticataract Agents; Treatment of Substance Dependency; Obsessive-Compulsive Disorder (OCD), Treatment of
DOM_SIM_049	Lansoprazole	Launched-1992	H+/K+-ATPase Inhibitors	Type 1 Diabetes, Agents for; Antiulcer Drugs; Treatment of Upper Respiratory Tract Disorders; Agents for Gastritis; Gastroesophageal Reflux Disease, Agents for; Non-Ulcer Dyspepsia, Agents for; Gastric Antisecretory Drugs; Esophageal Diseases, Treatment of; Anti-Helicobacter Pylori Agents; Liver Cancer Therapy
DOM_SIM_050	Naringeninic acid	Clinical	Antioxidants	Antiulcer Drugs
DOM_SIM_051	Nicotine	Launched	Nicotinic Receptor Agonists	Antiparkinsonian Drugs; Inflammatory Bowel Disease, Agents for; Extrapyramidal Disorders, Treatment of; Cognition Disorders, Treatment of; Nausea and Vomiting, Treatment of; Smoking Cessation, Aid to; Hematologic Agents (Miscellaneous)
DOM_SIM_052	(-)-Linalool	Clinical		
DOM_SIM_053	Adefovir	Clinical	DNA Polymerase Inhibitors	Anti-Hepatitis B Virus Drugs; Anti-HIV Agents; Antiviral Drugs
DOM_SIM_054	Metirosine	Launched-1979	Tyrosine 3-Monooxygenase (TH) Inhibitors	Endocrine Cancer Therapy
DOM_SIM_055	Luminol sodium salt	Launched-1997	IL-6 Production Inhibitors	Immunomodulators; Inflammation, Treatment of; Antiarthritic Drugs; Antipsoriatics
DOM_SIM_056	10290834			
DOM_SIM_057	Torcitabine	Phase I/II	DNA Polymerase Inhibitors	Anti-Hepatitis B Virus Drugs
DOM_SIM_058	Nevirapine	Launched-1996	Reverse Transcriptase/Ribonuclease H (HIV-1) Inhibitors	Anti-HIV Agents
DOM_SIM_059	Trientine hydrochloride	Launched-1986	Telomerase Reverse Transcriptase (TERT) Inhibitors	Antagonists to Metals; Oncolytic Drugs; Wilson Disease, Agent for; Diabetic Myocardiopathy, Agents for
DOM_SIM_060	Oxfenicine	Clinical	Carnitine O-Palmitoyltransferase 1 (CPT-1) Inhibitors	Angina pectoris, Treatment of; Heart Failure Therapy
DOM_SIM_061	D-Methionine	Phase II	Free Radical Scavengers	Treatment of Mucositis; Radioprotectants/Radiomitigators; Chemoprotective Agents
DOM_SIM_062	Otenzepad	Phase III	Muscarinic M2 Receptor Antagonists	Antiarrhythmic Drugs
DOM_SIM_063	Orlipastat	Launched-1998	Pancreatic Triacylglycerol Lipase Inhibitors	Antiobesity Drugs; Lipoprotein Disorders, Treatment of ; Treatment of Eating Disorders
DOM_SIM_064	Retapamulin	Launched-2007	50S Ribosomal Protein Inhibitors	
DOM_SIM_065	Desogestrel	Launched-1999	Progesterone Receptor Agonists	Oral Contraceptives; Gynecological Disorders, Treatment of ; Acne Therapy
DOM_SIM_066	Carmofur	Launched-1981	Thymidylate Synthase Inhibitors	Oncolytic Drugs
DOM_SIM_067	Carebastine	Pre-Registered	Histamine H1 Receptor Antagonists	Drugs for Allergic Rhinitis; Antiallergic Ophthalmic Agents; Antiallergy/Antiasthmatic Drugs
DOM_SIM_068	Amlexanox	Launched-1987	Penicillin-Binding Protein (PBP) (Bacterial) Inhibitors	Wound-Healing Agents; Antiallergy/Antiasthmatic Drugs; Treatment of Mucositis
DOM_SIM_069	Chlormadinone acetate	Launched	Progesterone Receptor Agonists	Treatment of Dysmenorrhea; Prostate Cancer Therapy; Benign Prostatic Hyperplasia Therapy; Endometriosis Therapy
DOM_SIM_070	Adrenaline	Launched	Carbonic Anhydrase Activators	Allergy, Treatment of; Antiallergy/Antiasthmatic Drugs
DOM_SIM_071	Moguisteine	Phase II		
DOM_SIM_072	Climbazole	Launched		Antifungal Agents; Dermatologic Drugs
DOM_SIM_073	Tributyrin	Phase II	Histone Deacetylase (HDAC) Inhibitors	Leukemia Therapy; Solid Tumors Therapy
DOM_SIM_074	Adrafinil	Launched-1985		CNS Stimulants; Antidepressants
DOM_SIM_075	ID-1101	Phase II	Insulin Secretagogues	Antiobesity Drugs; Type 2 Diabetes, Agents for
DOM_SIM_076	SN-38	Clinical	beta-Amyloid (Abeta) Production Inhibitors	Oncolytic Drugs; Alzheimer's Dementia, Treatment of ; Cancer of Unspecified Body Location/System
DOM_SIM_077	Oltipraz	Phase II	Nuclear Factor Erythroid 2-Related Factor 2 (NFE2-Related Factor 2; NFE2L2; NRF2) Activators	Oncolytic Drugs; Chemopreventive Agents; Treatment of Mucositis; Liver and Biliary Tract Disorders, Treatment of
DOM_SIM_078	Rupatadine fumarate	Launched-2003	Histamine H1 Receptor Antagonists	Drugs for Allergic Rhinitis; Urticaria, Treatment for; Dermatologic Drugs
DOM_SIM_079	Pravadoline	Phase II	Cannabinoid CB1 Receptor Agonists	Non-Opioid Analgesics
DOM_SIM_080	2-Deoxy-D-glucose	Phase I/II		Prostate Cancer Therapy; Antimalarials; Antiepileptic Drugs; Solid Tumors Therapy; Antineoplastic Enhancing Agents
DOM_SIM_081	asymmetrical-dimethylarginine	Clinical	Nitric Oxide Synthase Inhibitors	Cardiovascular Diseases (Not Specified)
DOM_SIM_082	Hydralazine	Launched-1952	Myeloperoxidase Inhibitors	Hypertension, Treatment of; Vasodilators
DOM_SIM_083	Streptozocin	Launched	DNA Alkylating Drugs	Pancreatic Cancer Therapy
DOM_SIM_084	Linifanib	Phase III	FLT3 (FLK2/STK1) Inhibitors	Treatment of Female Sexual Dysfunction; Age-Related Macular Degeneration, Treatment of; Non-Small Cell Lung Cancer Therapy; Breast Cancer Therapy; Renal Cancer Therapy; Hematological Cancer Therapy; Colorectal Cancer Therapy; Liver Cancer Therapy
DOM_SIM_085	Entinostat	Phase III	Histone Deacetylase 2 (HDAC2) Inhibitors	Prostate Cancer Therapy; Multiple Myeloma Therapy; Lymphocytic Leukemia Therapy; Myelodysplastic Syndrome Therapy; Lymphoma Therapy; Non-Small Cell Lung Cancer Therapy; Melanoma Therapy; Antipsychotic Drugs; Breast Cancer Therapy; Ovarian Cancer Therapy; Oncolytic Drugs; Digestive/Gastrointestinal Cancer Therapy; Pancreatic Cancer Therapy; Liver and Biliary Tract Disorders, Treatment of; Female Reproductive System Cancer Therapy; Colorectal Cancer Therapy; Myeloid Leukemia Therapy; Renal Cancer Therapy; Allergic Skin Disorders, Treatment for; Non-Hodgkin's Lymphoma Therapy; Solid Tumors Therapy
DOM_SIM_086	Desvenlafaxine succinate	Launched-2008	Norepinephrine Reuptake Inhibitors	Treatment of Postmenopausal Syndrome ; Fibromyalgia, Treatment of; Neuropathic Pain, Treatment of; Antidepressants
DOM_SIM_087	Pramiracetam hydrochloride	Launched-1993	Prolyl Endopeptidase (prolyl oligopeptidase; POP) Inhibitors	Cognition Disorders, Treatment of
DOM_SIM_088	9863537			
DOM_SIM_089	Didox	Phase II	Antimetabolites	Anti-HIV Agents; Oncolytic Drugs
DOM_SIM_090	Clindamycin hydrochloride	Launched-1968	16S Ribosomal Protein Inhibitors	Antibiotics; Acne Therapy
DOM_SIM_091	Carnosine	Phase II	AGE Inhibitors (Maillard's Reaction Inhibitors)	Psychiatric Disorders (Not Specified); Immunomodulators; Neurologic Drugs (Miscellaneous); Cognition Disorders, Treatment of; Heart Failure Therapy
DOM_SIM_092	Cilastatin sodium	Launched-1985	Dehydropeptidase I Inhibitors	beta-Lactam Enhancers; Inhibitors of Degradation of Drugs
DOM_SIM_093	Rivaroxaban	Launched-2008	Coagulation Factor Xa Inhibitors	
DOM_SIM_094	Enzastaurin hydrochloride	Phase III	Phosphatidylinositol 3-Kinase (PI3K) Inhibitors	Prostate Cancer Therapy; Multiple Myeloma Therapy; Non-Small Cell Lung Cancer Therapy; Neurologic Cancer Therapy; Oncolytic Drugs; Breast Cancer Therapy; Ovarian Cancer Therapy; Pancreatic Cancer Therapy; Colorectal Cancer Therapy; Glioblastoma Multiforme Therapy; Renal Cancer Therapy; Antineoplastic Enhancing Agents; Non-Hodgkin's Lymphoma Therapy; Pulmonary Hypertension, Treatment of; Solid Tumors Therapy
DOM_SIM_095	BMS-754807	Phase II	IGF-1R Inhibitors	Breast Cancer Therapy
DOM_SIM_096	Alogliptin benzoate	Launched-2010	Dipeptidyl Peptidase IV (CD26; DPP-IV; DP-IV) Inhibitors	Type 2 Diabetes, Agents for
DOM_SIM_097	Pidotimod	Launched-1993		
DOM_SIM_098	Equol	Phase II	Estrogen Receptor (ER) beta Agonists	Benign Prostatic Hyperplasia Therapy; Treatment of Hot Flushes; Alzheimer's Dementia, Treatment of ; Agents for Osteopetrosis
DOM_SIM_099	SAB-378	Discontinued	Cannabinoid CB2 Receptor Agonists	Analgesic Drugs
DOM_SIM_100	Resveratrol	Phase II	NF-kappaB (NFKB) Modulators	Other Ocular Medications; Multiple Myeloma Therapy; Antiobesity Drugs; Huntington's Disease, Treatment of; Neurologic Drugs (Miscellaneous); Neurological Genetic Disorders, Treatment of ; Therapy of Inborn Errors of Metabolism; Treatment of Disorders of the Coronary Arteries and Atherosclerosis; Neuromuscular Genetic Disorders, Treatment of; Osteoarthritis, Treatment of; Anti-Herpes Virus Drugs; Oncolytic Drugs; Chemopreventive Agents; Female Infertility, Agents for; Alzheimer's Dementia, Treatment of ; Chemoprotective Agents; Antipsoriatics; Colorectal Cancer Therapy; Type 2 Diabetes, Agents for; Diabetic Nephropathy, Agents for
DOM_SIM_101	SDZ-201 106 (+/-)	Phase II		Heart Failure Therapy
DOM_SIM_102	Doripenem	Launched-2005	Dehydropeptidase I Inhibitors	
DOM_SIM_103	Eniluracil	Phase II	Dihydropyrimidine Dehydrogenase Inhibitors	Inhibitors of the Degradation of Anticancer Drugs; Breast Cancer Therapy; Disorders Associated with Cancer Therapy, Treatment of; Pancreatic Cancer Therapy; Colorectal Cancer Therapy; Antineoplastic Enhancing Agents; Liver Cancer Therapy
DOM_SIM_104	Malotilate	Launched-1985		
DOM_SIM_105	2-methoxyestradiol		Hypoxia Inducible Factor 1-alpha (HIF-1alpha) Inhibitors	
DOM_SIM_106	Rabusertib	Phase II	Checkpoint Kinase 1 (Chk1) Inhibitors	Non-Small Cell Lung Cancer Therapy; Pancreatic Cancer Therapy
DOM_SIM_107	Daporinad	Phase II	Nicotinamide Phosphoribosyltransferase (NAmPRTase; Nampt) Inhibitors	Leukemia Therapy; Immunosuppressants; Melanoma Therapy; Oncolytic Drugs; Non-Hodgkin's Lymphoma Therapy; Treatment of Autoimmune Diseases; Antineoplastic Enhancing Agents
DOM_SIM_108	Rilpivirine hydrochloride	Launched-2011	Reverse Transcriptase/Ribonuclease H (HIV-1) Inhibitors	Anti-HIV Agents
DOM_SIM_109	FK-962	Discontinued		Alzheimer's Dementia, Treatment of
DOM_SIM_110	Riociguat	Launched-2013	Soluble Guanylate Cyclase (sGC) Activators	Cystic Fibrosis, Treatment of ; Raynaud's Phenomenon, Treatment for ; Pulmonary Hypertension, Treatment of; Treatment of Autoimmune Diseases
DOM_SIM_111	Drotaverine hydrochloride	Launched	Phosphodiesterase PDE4 Inhibitors	Antispastic Drugs
DOM_SIM_112	Tiludronate disodium	Launched-1995	Parathyroid Hormone Receptor Antagonists	Treatment of Paget's Disease; Ear disorders, treatment of
DOM_SIM_113	Bromfenac	Phase II	Prostaglandin G/H Synthase 2 (PTGS2; COX-2) Inhibitors	Non-Opioid Analgesics
DOM_SIM_114	Amuvatinib	Discontinued	Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret (RET; CDHF12; PTC) Inhibitors	Small Cell Lung Cancer Therapy; Lymphoma Therapy; Oncolytic Drugs; Glioblastoma Multiforme Therapy; Solid Tumors Therapy
DOM_SIM_115	Mizoribine	Launched-1984	Inosine 5'-Monophosphate Dehydrogenase (IMPDH) Inhibitors	Treatment of Renal Diseases; Immunosuppressants; Treatment of Transplant Rejection; Rheumatoid Arthritis, Treatment of; Treatment of Autoimmune Diseases
DOM_SIM_116	Methyclothiazide	Launched-1960		Diuretics; Hypertension, Treatment of
DOM_SIM_117	Tolvaptan	Launched-2009	Vasopressin (AVP) V2 Receptor Antagonists	Treatment of Renal Diseases; Renal and Urinary System Genetic Disorders, Treatment of ; Liver and Biliary Tract Disorders, Treatment of; Heart Failure Therapy; Cardiovascular Diseases (Not Specified); Renal Failure, Agents for; Cancer Associated Disorders, Treatment of
DOM_SIM_118	Chloroprocaine hydrochloride	Launched		Analgesic Drugs
DOM_SIM_119	Pyridoxamine	Phase II	AGE Inhibitors (Maillard's Reaction Inhibitors)	Antipsychotic Drugs; Urolithiasis, Agents for; Diabetic Nephropathy, Agents for; Renal Failure, Agents for
DOM_SIM_120	Lerisetron	Phase III	5-HT3 Receptor Antagonists	Nausea and Vomiting, Treatment of
DOM_SIM_121	Tolperisone hydrochloride	Launched-1962		Muscle Spasms, Drugs for
DOM_SIM_122	3-Phenoxypyridine	Phase II		Cognition Disorders, Treatment of
DOM_SIM_123	Pelitinib	Phase II	EGFR (HER1; erbB1) Inhibitors	Non-Small Cell Lung Cancer Therapy; Colorectal Cancer Therapy; Solid Tumors Therapy; Head and Neck Cancer Therapy
DOM_SIM_124	Baricitinib	Launched-2017	Jak1 Inhibitors	Treatment of Musculoskeletal & Connective Tissue Diseases (Miscellaneous); Immunosuppressants; Atopic Dermatitis, Agents for; Inflammation, Treatment of; Rheumatoid Arthritis, Treatment of; Vasculitis, Agents for; Psoriatic Arthritis, Treatment of ; Systemic Lupus Erythematosus, Agents for; Dermatologic Drugs; Antipsoriatics; Treatment of Autoimmune Diseases; Diabetic Nephropathy, Agents for
DOM_SIM_125	Etravirine	Launched-2008	Reverse Transcriptase/Ribonuclease H (HIV-1) Inhibitors	Anti-HIV Agents
DOM_SIM_126	GW-842166X	Phase II	Cannabinoid CB2 Receptor Agonists	Non-Opioid Analgesics
DOM_SIM_127	Salsalate	Launched	NF-kappaB (NFKB) Activation Inhibitors	Osteoarthritis, Treatment of; Rheumatoid Arthritis, Treatment of; Type 2 Diabetes, Agents for
DOM_SIM_128	Coluracetam	Discontinued	Acetylcholine Release Enhancers	Anxiolytics; Alzheimer's Dementia, Treatment of ; Antidepressants
DOM_SIM_129	MB05032	Phase II	Fructose-1,6-Bisphosphatase Inhibitors	Type 2 Diabetes, Agents for
DOM_SIM_130	Isofloxythepin	Launched-1989		Antipsychotic Drugs
DOM_SIM_131	(-)-2,3-Pinanediol	Clinical		Dermatologic Drugs
DOM_SIM_132	AT7519	Phase I	Cyclin-Dependent Kinase 9 (CDK9) Inhibitors	Lymphocytic Leukemia Therapy; Multiple Myeloma Therapy; Solid Tumors Therapy; Non-Hodgkin's Lymphoma Therapy
DOM_SIM_133	Tretinoin	Launched-1962	Nuclear Receptor ROR-beta (RORB) Ligands	Keratolytics; Myelodysplastic Syndrome Therapy; Multiple Myeloma Therapy; Leukemia Therapy; Stroke, Treatment of; Renal Cancer Therapy; Urologic Drugs; Acne Therapy; Solid Tumors Therapy
DOM_SIM_134	Omecamtiv mecarbil	Phase III	Cardiac Myosin Activators	Treatment of Disorders of the Coronary Arteries and Atherosclerosis; Angina pectoris, Treatment of; Heart Failure Therapy
DOM_SIM_135	Sotrastaurin	Phase I/II	Protein Kinase PKC delta Inhibitors	Immunomodulators; Inflammatory Bowel Disease, Agents for; Treatment of Transplant Rejection; Melanoma Therapy; Ophthalmic Drugs; Antipsoriatics; Non-Hodgkin's Lymphoma Therapy
DOM_SIM_136	Sophocarpine	Clinical		Oncolytic Drugs; Bronchodilators
DOM_SIM_137	Artesunate	Launched-1987	Apoptosis Inducers	Antimalarials; Anti-Cytomegalovirus Drugs; Breast Cancer Therapy
DOM_SIM_138	N-Acetylcarnosine	Launched	Antioxidants	Anticataract Agents
DOM_SIM_139	Talinolol	Launched	beta1-Adrenoceptor Antagonists	Hypertension, Treatment of; Angina pectoris, Treatment of; Heart Failure Therapy; Antiarrhythmic Drugs
DOM_SIM_140	Methiopril	Phase II	Angiotensin-I Converting Enzyme (ACE) Inhibitors	Hypertension, Treatment of; Heart Failure Therapy
DOM_SIM_141	Uridine triacetate	Launched-2016		Bipolar Disorder, Treatment of; Treatment of Renal Diseases; Neurologic Drugs (Miscellaneous); Autism, Treatment of; Therapy of Inborn Errors of Metabolism; Gastric Cancer Therapy; Specific Antidotes; Antidepressants; Pancreatic Cancer Therapy; Treatment of Disorders of Purine and Pyrimidine Metabolism; Colorectal Cancer Therapy; Chemoprotective Agents
DOM_SIM_142	Ezetimibe	Launched-2002	Niemann-Pick C1-Like protein 1 (NPC1L1) Inhibitors	Treatment of Diabetic Complications; Lipoprotein Disorders, Treatment of ; Liver and Biliary Tract Disorders, Treatment of; Cardiovascular Diseases (Not Specified); Anti-Hepatitis C Virus Drugs; Anti-Hepatitis D Virus Drugs
DOM_SIM_143	Clindamycin phosphate	Launched		Antibacterial Drugs
DOM_SIM_144	Mirabegron	Launched-2011	beta3-Adrenoceptor Agonists	Urinary Incontinence Therapy; Treatment of Erectile Dysfunction; Urologic Drugs; Pulmonary Hypertension, Treatment of; Type 2 Diabetes, Agents for
DOM_SIM_145	Ozagrel sodium	Launched-1988	Thromboxane Synthase Inhibitors	Dry Eye Syndrome, Treatment for; Cerebrovascular Diseases, Treatment of
DOM_SIM_146	Ataluren	Launched-2014	Nonsense Mutation Suppressors	Metabolic and Nutritional Genetic Disorders, Treatment of ; Cystic Fibrosis, Treatment of ; Therapy of Inborn Errors of Metabolism; Hemophilia, Agents for; Antiepileptic Drugs; Muscular Dystrophy, Agents for; Ocular Genetic Disorders, Treatment of
DOM_SIM_147	Sofalcone	Launched-1984		Antiulcer Drugs; Agents for Gastritis
DOM_SIM_148	Sivifene	Phase II	Estrogen Receptor (ER) Antagonists	Immunomodulators; Premalignant Conditions Therapy; Oncolytic Drugs; Colorectal Cancer Therapy
DOM_SIM_149	5-Aminolevulinic acid hydrochloride	Launched-2000		Antianemics; Actinic Keratoses, Agents for; Neurologic Drugs (Miscellaneous); Inflammatory Bowel Disease, Agents for; Basal Cell Carcinoma Therapy; Antimalarials; Restenosis Treatment of; Premalignant Conditions Therapy; Neurologic Cancer Therapy; Skin Cancer Therapy; Antifungal Agents; Antidiabetic Drugs; Dermatologic Drugs; Acne Therapy; Diagnosis of Cancer; Esophageal Diseases, Treatment of; Ischemia, Treatment of; Type 2 Diabetes, Agents for
DOM_SIM_150	spaglumic-acid	Phase II	Mediator Release Inhibitors	Antiallergy/Antiasthmatic Drugs
DOM_SIM_151	Clevidipine	Launched-2008	Calcium Channel Blockers	Hypertension, Treatment of
DOM_SIM_152	Idelalisib	Launched-2014	P-Glycoprotein (MDR-1; ABCB1) Inhibitors	Lymphocytic Leukemia Therapy; Drugs for Allergic Rhinitis; Lymphoma Therapy; Non-Small Cell Lung Cancer Therapy; Amyloidosis, Treatment of; Oncolytic Drugs; Inflammation, Treatment of; Pancreatic Cancer Therapy; Hematological Cancer Therapy; Hematopoiesis Disorders Therapy; Non-Hodgkin's Lymphoma Therapy
DOM_SIM_153	Tideglusib	Phase II/III	Glycogen Synthase Kinase 3 beta (GSK3B; GSK-3beta) Inhibitors	Neurologic Drugs (Miscellaneous); Neurological Genetic Disorders, Treatment of ; Autism, Treatment of; Alzheimer's Dementia, Treatment of ; Cerebrovascular Diseases, Treatment of
DOM_SIM_154	Pazopanib hydrochloride	Launched-2009	VEGFR-3 (FLT4) Inhibitors	Sarcoma Therapy; Multiple Myeloma Therapy; Age-Related Macular Degeneration, Treatment of; Small Cell Lung Cancer Therapy; Respiratory/Thoracic Cancer Therapy; Prostate Cancer Therapy; Bone Cancer Therapy; Hematologic Genetic Disorders, Treatment of ; Endocrine Cancer Therapy; Non-Small Cell Lung Cancer Therapy; Cervical Cancer Therapy; Melanoma Therapy; Ovarian Cancer Therapy; Breast Cancer Therapy; Oncolytic Drugs; Digestive/Gastrointestinal Cancer Therapy; Cancer of Unspecified Body Location/System; Renal Cancer Therapy; Antipsoriatics; Genitourinary Cancer Therapy; Colorectal Cancer Therapy; Glioblastoma Multiforme Therapy; Osteosarcoma Therapy; Cardiovascular Diseases (Not Specified); Liver Cancer Therapy; Head and Neck Cancer Therapy
DOM_SIM_155	Clevudine	Launched-2007	DNA Polymerase Inhibitors	Anti-Hepatitis B Virus Drugs
DOM_SIM_156	Benzoyl peroxide	Launched		Acne Therapy
DOM_SIM_157	Erbocain	Launched	Drugs Acting on Sodium Channels	Anesthetic Drugs; Antiarrhythmic Drugs
DOM_SIM_158	Carbazochrome sodium sulfonate	Launched-1956		
DOM_SIM_159	Creatine	Launched		Neurologic Drugs (Miscellaneous); Huntington's Disease, Treatment of; Antiparkinsonian Drugs; Amyotrophic Lateral Sclerosis, Agents for; Cancer Associated Disorders, Treatment of; Muscular Dystrophy, Agents for
DOM_SIM_160	(+)-Matrine	Clinical	Caspase Activators	Anti-Hepatitis B Virus Drugs; Analgesic Drugs; Oncolytic Drugs
DOM_SIM_161	Piceid	Launched	Xanthine Oxidase Inhibitors	Hemostatics; Asthma Therapy; Antiplatelet Therapy; Analgesic Drugs; Ischemic Stroke, Treatment of; Antiinfectives (Not Specified); Irritable Bowel Syndrome, Agents for
DOM_SIM_162	8-Hydroxyquinoline		Chelating Agents	Antimycobacterial Agents; Breast Cancer Therapy; Dermatologic Drugs
DOM_SIM_163	Diethylstilbestrol	Launched	Estrogen Receptor (ER) Agonists	Prostate Cancer Therapy; Breast Cancer Therapy
DOM_SIM_164	Sarcosine	Phase II	GlyT-1 Inhibitors	Psychiatric Disorders (Not Specified); Antipsychotic Drugs; Antidepressants; Obsessive-Compulsive Disorder (OCD), Treatment of
DOM_SIM_165	Nitisinone	Launched-2002	4-Hydroxyphenylpyruvate Dioxygenase (4HPPD) Inhibitors	Antiparkinsonian Drugs; Thyroid Disease Therapy; Therapy of Inborn Errors of Metabolism; Dermatologic Drugs; Restless Legs Syndrome, Treatment of
DOM_SIM_166	Creatinol phosphate	Launched		Neurologic Drugs (Miscellaneous); Acute Myocardial Infarction, Treatment of
DOM_SIM_167	Eplivanserin	Discontinued	5-HT2A Receptor Antagonists	Sleep Apnea, Treatment of; Fibromyalgia, Treatment of; Antipsychotic Drugs; Sleep Disorders, Treatment of; Antidepressants
DOM_SIM_168	Pyrazoloacridine	Phase II	DNA-Intercalating Drugs	Neurologic Cancer Therapy; Melanoma Therapy; Ovarian Cancer Therapy; Brain Cancer Therapy; Bladder Cancer Therapy ; Breast Cancer Therapy; Pancreatic Cancer Therapy; Glioblastoma Multiforme Therapy; Solid Tumors Therapy
DOM_SIM_169	Aminobenzoate potassium	Launched		Treatment of Male Sexual Dysfunction; Scleroderma, Agents for; Analgesic Drugs; Idiopathic Inflammatory Myopathies, Agents for; Treatment of Other Autoimmune Disorders; Dermatologic Drugs
DOM_SIM_170	Retinol acetate	Launched	Antioxidants	Chemopreventive Agents; Therapy of Vitamin-Related Disorders
DOM_SIM_171	Phenylbutyric acid sodium salt	Launched-1996	Pharmacological Chaperones	Prostate Cancer Therapy; Aminoacidopathies, Treatment for; Huntington's Disease, Treatment of; Lymphoma Therapy; Therapy of Inborn Errors of Metabolism; Cystic Fibrosis, Treatment of ; Neuromuscular Genetic Disorders, Treatment of; Brain Cancer Therapy; Alzheimer's Dementia, Treatment of ; Glioblastoma Multiforme Therapy; Myeloid Leukemia Therapy; Colorectal Cancer Therapy
DOM_SIM_172	Cinromide	Clinical		Antiepileptic Drugs
DOM_SIM_173	Carglumic acid	Launched-2003	Carbamoyl Phosphate Synthetase 1 (CPS1) Activators	Metabolic Disorders (Not Specified)
DOM_SIM_174	Vitamin E	Launched	Antioxidants	
DOM_SIM_175	Nadifloxacin	Launched-1993	DNA Topoisomerase IV (Staphylococcus aureus) Inhibitors	Antibacterial Drugs; Acne Therapy
DOM_SIM_176	Methypranolol	Launched-1982	beta-Adrenoceptor Antagonists	Antiglaucoma Agents
DOM_SIM_177	Mofezolac	Launched-1994	Prostaglandin G/H Synthase 1 (PTGS1; COX-1) Inhibitors	Non-Opioid Analgesics
DOM_SIM_178	Norethindrone acetate	Launched	Progesterone Receptor Agonists	Contraceptives; Gynecological Disorders, Treatment of ; Endometriosis Therapy
DOM_SIM_179	Methyl nicotinate	Clinical		Treatment of Diabetic Complications
DOM_SIM_180	2,3-cis/exo-Camphanediol	Clinical		Dermatologic Drugs
DOM_SIM_181	Coumarin	Clinical		Antidiabetic Drugs
DOM_SIM_182	Trimebutine maleate	Launched-1970	Opioid Receptor Agonists	Antispasmodics; Irritable Bowel Syndrome, Agents for
DOM_SIM_183	L-Citrulline	Phase III		Sepsis, Treatment of; Disorders of Sexual Function and Reproduction, Treatment of; Peripheral Arterial Disease, Treatment of; Pulmonary Hypertension, Treatment of; Muscular Dystrophy, Agents for; Hematologic Agents (Miscellaneous); Respiratory Disorders (Not Specified)
DOM_SIM_184	(+)-Taxifolin	Clinical	NF-kappaB (NFKB) Modulators	Anti-HIV Agents; Atherosclerosis Therapy; Ischemic Stroke, Treatment of; Alzheimer's Dementia, Treatment of ; Lipoprotein Disorders, Treatment of ; Anti-Hepatitis A Virus Drugs
DOM_SIM_185	Tropesin	Launched-1989	Cyclooxygenase-3 Inhibitors	
DOM_SIM_186	Emorfazone	Launched-1984		
DOM_SIM_187	Antioxine	Clinical	Quorum Sensing Signaling Inhibitors	Antiplatelet Therapy; Oncolytic Drugs; Antifungal Agents; Antibacterial Drugs
DOM_SIM_188	18beta-Glycyrrhetinic acid	Launched	Multidrug Resistance-Associated Protein 1 (MRP-1; ABCC1) Inhibitors	Treatment of Renal Diseases; Antiulcer Drugs; Dental Agents; Antiallergy/Antiasthmatic Drugs; Oncolytic Drugs; Rheumatoid Arthritis, Treatment of; Antiviral Drugs
DOM_SIM_189	Chuanxiongzine	Launched		Stroke, Treatment of; Angina pectoris, Treatment of
DOM_SIM_190	L-Tryptophan	Launched		Mood Disorders, Treatment of; Alzheimer's Dementia, Treatment of
DOM_SIM_191	Sulindac	Launched-1976	ABCC1 Expression Enhancers	Treatment of Gout; Non-Opioid Analgesics; Osteoarthritis, Treatment of; Melanoma Therapy; Ankylosing Spondylitis, Treatment of; Chemopreventive Agents; Rheumatoid Arthritis, Treatment of
DOM_SIM_192	Caprylic acid	Launched	Antioxidants	Acne Therapy
DOM_SIM_193	Etiracetam	Phase II		Cognition Disorders, Treatment of
DOM_SIM_194	Guanabenz acetate	Launched-1976	alpha2-Adrenoceptor Agonists	Hypertension, Treatment of; Multiple Sclerosis, Agents for; Lesions of the Spinal Cord and Related Structures, Treatment of
DOM_SIM_195	diiodothyropropionic-acid	Discontinued		Mental Retardation, Treatment of; Lipoprotein Disorders, Treatment of ; Heart Failure Therapy
DOM_SIM_196	Lumiracoxib	Launched-2005	Prostaglandin G/H Synthase 2 (PTGS2; COX-2) Inhibitors	Treatment of Dysmenorrhea; Treatment of Gout; Non-Opioid Analgesics; Osteoarthritis, Treatment of; Rheumatoid Arthritis, Treatment of
DOM_SIM_197	Lipoic acid	Launched-1955	Antioxidants	Multiple Sclerosis, Agents for; Neuropathic Pain, Treatment of; Treatment of Poisoning; Hearing loss, treatment of; Diabetic Neuropathy, Agents for; Type 2 Diabetes, Agents for
DOM_SIM_198	Fludrocortisone acetate	Launched		Adrenocortical Dysfunction Therapy
DOM_SIM_199	Salicylic acid	Launched		Antipsoriatics; Dermatologic Drugs; Acne Therapy
DOM_SIM_200	5-(Hydroxymethyl)furan-2-carbaldehyde	Phase II	DNA Polymerase lambda Inhibitors	Sickle Cell Anemia, Agents for; Treatment of Osteoporosis
DOM_SIM_201	LORNOXICAM	Launched - 1997		
DOM_SIM_202	Nefiracetam	Phase III		Stroke, Treatment of; Alzheimer's Dementia, Treatment of
DOM_SIM_203	Trehalose	Phase II/III	Pharmacological Chaperones	Huntington's Disease, Treatment of; Therapy of Inborn Errors of Metabolism; Neuromuscular Genetic Disorders, Treatment of
DOM_SIM_204	Metazosin	Phase III	alpha1-Adrenoceptor Antagonists	Benign Prostatic Hyperplasia Therapy; Heart Failure Therapy
DOM_SIM_205	(+)-Cedrol	Phase II	Butyrylcholinesterase (BuChE) Inhibitors	Treatment of Postmenopausal Syndrome ; Sedative/Hypnotics
DOM_SIM_206	Ampiroxicam	Launched-1994	Cyclooxygenase (COX) Inhibitors	
DOM_SIM_207	Azelaic acid	Launched-1989	Thioredoxin (TXN; TRX; TRDX) Inhibitors	Dermatologic Drugs; Acne Therapy
DOM_SIM_208	Adenosine	Launched-1989	Adenosine Receptor Agonists	Diagnosis of Cardiovascular Disorders; Analgesic Drugs; Acute Myocardial Infarction, Treatment of; Vasodilators; Antiarrhythmic Drugs
DOM_SIM_209	Histamine dihydrochloride	Launched-1964	NADPH Oxidase (NOX) Inhibitors	Sarcoma Therapy; Prostate Cancer Therapy; Immunomodulators; Migraine, Prophylactic Treatment of; Leukemia Therapy; Melanoma Therapy; Treatment of Mucositis; Disorders Associated with Cancer Therapy, Treatment of; Medical Diagnosis; Liver and Biliary Tract Disorders, Treatment of; Myeloid Leukemia Therapy; Colorectal Cancer Therapy; Renal Cancer Therapy; Anti-Hepatitis C Virus Drugs
DOM_SIM_210	Piperine	Clinical	TRPV1 (Vanilloid VR1 Receptor) Agonists	Non-Opioid Analgesics; Antiepileptic Drugs; Oncolytic Drugs; Pharmacological Tools; Antiarthritic Drugs; Antidepressants; Lipoprotein Disorders, Treatment of ; Dermatologic Drugs
DOM_SIM_211	Cyamemazine	Launched-1972	5-HT2C Receptor Antagonists	Anxiolytics; Antipsychotic Drugs
DOM_SIM_212	GLUCOSAMINE HYDROCHLORIDE			
DOM_SIM_213	HQK-1001	Phase II		Antianemics; Sickle Cell Anemia, Agents for
DOM_SIM_214	9-Nitrocamptothecin	Phase III	DNA Topoisomerase I Inhibitors	Sarcoma Therapy; Small Cell Lung Cancer Therapy; Myelodysplastic Syndrome Therapy; Prostate Cancer Therapy; Lymphoma Therapy; Anti-HIV Agents; Gastric Cancer Therapy; Melanoma Therapy; Breast Cancer Therapy; Ovarian Cancer Therapy; Brain Cancer Therapy; Pancreatic Cancer Therapy; Colorectal Cancer Therapy; Myeloid Leukemia Therapy; Head and Neck Cancer Therapy
DOM_SIM_215	(S)-5-Amino-2-(2-aminoacetamido)-5-oxopentanoic acid	Phase II		Treatment of Opioid Dependency; Chemoprotective Agents
DOM_SIM_216	Hexamethylenebisacetamide	Phase II		Oncolytic Drugs
DOM_SIM_217	D-Penicillamine	Launched-1953		Treatment of Renal Diseases; Rheumatoid Arthritis, Treatment of; Wilson Disease, Agent for
DOM_SIM_218	Dimethyl fumarate	Launched-2013	Nuclear Factor Erythroid 2-Related Factor 2 (NFE2-Related Factor 2; NFE2L2; NRF2) Activators	Immunomodulators; Lymphocytic Leukemia Therapy; Treatment of Musculoskeletal & Connective Tissue Diseases (Miscellaneous); Neurological Genetic Disorders, Treatment of ; Multiple Sclerosis, Agents for; Immunologic Neuromuscular Disorders, Treatment of; Rheumatoid Arthritis, Treatment of; Antipsoriatics; Glioblastoma Multiforme Therapy; Psoriatic Arthritis, Treatment of ; Pulmonary Hypertension, Treatment of
DOM_SIM_219	O6-Benzylguanine	Phase III	O6-Alkylguanine-DNA Alkyltransferase (MGMT) Inhibitors	Antineoplastic Enhancing Agents
DOM_SIM_220	(-)-Cytisine	Launched-1964	Nicotinic alpha3beta4 Receptor Agonists	Antidepressants; Smoking Cessation, Aid to
DOM_SIM_221	Benfluron hydrochloride	Phase II		Oncolytic Drugs
DOM_SIM_222	Frentizol	Clinical		Immunosuppressants; Systemic Lupus Erythematosus, Agents for
DOM_SIM_223	Tocopherol acetate	Launched-1921	Antioxidants	Atopic Dermatitis, Agents for; Treatment of Nutritional Disorders
DOM_SIM_224	Acecainide hydrochloride	Phase III		Antiarrhythmic Drugs
DOM_SIM_225	Riboflavin	Launched-2016		Keratoconus, Treatment for; Ophthalmic Drugs; Therapy of Vitamin-Related Disorders
DOM_SIM_226	Alacepril	Launched-1988	Angiotensin-I Converting Enzyme (ACE) Inhibitors	Hypertension, Treatment of
DOM_SIM_227	Isobutyramide	Phase II		Hematopoietic Agents
DOM_SIM_228	Inositol	Launched		Anxiolytics; Chemopreventive Agents; Antidepressants; Antidiabetic Drugs
DOM_SIM_229	Nitazoxanide	Launched-1996	Pyruvate Synthase (Pyruvate-Ferredoxin Oxidoreductase; PFOR) (Protozoal) Inhibitors	Treatment of Protozoal Diseases; Anti-Influenza Virus Drugs; Anti-Hepatitis B Virus Drugs; Oncolytic Drugs; Antiviral Drugs; Agents for Liver Fibrosis; Antibacterial Drugs; Anti-Hepatitis C Virus Drugs; Treatment of Tuberculosis; Anti-Helicobacter Pylori Agents
DOM_SIM_230	Zanamivir	Launched-1999	Neuraminidase (Sialidase) (Influenza Virus) Inhibitors	Anti-Influenza Virus Drugs
DOM_SIM_231	Riboflavin 5'-phosphate sodium	Launched		Septic Shock, Treatment of ; Therapy of Vitamin-Related Disorders
DOM_SIM_232	Bucladesine sodium	Launched-1985	cAMP-Dependent Protein Kinase (PKA) Activators	Wound-Healing Agents
DOM_SIM_233	Palmidrol	Launched	PPARalpha Agonists	Other Ocular Medications; Neurodegenerative Diseases, Treatment of; Analgesic Drugs; Mood Disorders, Treatment of; Atopic Dermatitis, Agents for; Neuropathic Pain, Treatment of; Inflammation, Treatment of; Immunostimulants; Antiglaucoma Agents
DOM_SIM_234	Tretazicar	Phase II	DNA-Damaging Drugs	Liver Cancer Therapy
DOM_SIM_235	Candesartan cilexetil	Launched-1997	Type-1 Angiotensin II Receptor (AGTR1; AT1) Antagonists	Diabetic Retinopathy, Agents for; Non-Opioid Analgesics; Restenosis Treatment of; Treatment of Cocaine Dependency; Antimigraine Drugs; Hypertension, Treatment of; Cognition Disorders, Treatment of; Stroke, Treatment of; Heart Failure Therapy; Diabetic Nephropathy, Agents for
DOM_SIM_236	Salicin	Phase II		Acute Attacks of Migraine, Treatment of
DOM_SIM_237	Imidafenacin	Launched-2007	Muscarinic M3 Receptor Antagonists	Urinary Incontinence Therapy
DOM_SIM_238	Dithiosteine	Launched-1995		Chronic Obstructive Pulmonary Diseases (COPD), Treatment of; Treatment of Poisoning; Chronic Obstructive Bronchitis, Agents for; Mucolytics
DOM_SIM_239	4',7-Dihydroxyisoflavanone	Clinical	Estrogen Receptor (ER) beta Agonists	Analgesic Drugs; Oncolytic Drugs; Bone Diseases, Treatment of; Pulmonary Hypertension, Treatment of
DOM_SIM_240	1-Methyl-D-tryptophan	Phase II/III	Indoleamine 2,3-dioxygenase 1 (IDO1; IDO) Inhibitors	Immunomodulators; Prostate Cancer Therapy; Non-Small Cell Lung Cancer Therapy; Melanoma Therapy; Brain Cancer Therapy; Breast Cancer Therapy; Pancreatic Cancer Therapy; Myeloid Leukemia Therapy
DOM_SIM_241	Gestodene	Phase II	Progesterone Receptor Agonists	Hormone Replacement Therapy; Treatment of Osteoporosis
DOM_SIM_242	(-)-Epigallocatechin gallate	Phase II/III	SGLT-1 Inhibitors	Antiparkinsonian Drugs; Actinic Keratoses, Agents for; Cognition Disorders, Treatment of; Multiple Sclerosis, Agents for; Chemopreventive Agents; Antineoplastic Antibiotics; Lipoprotein Disorders, Treatment of ; Alzheimer's Dementia, Treatment of ; Ophthalmic Drugs; Metabolic Disorders (Not Specified); Dermatologic Drugs; Agents for Liver Fibrosis; Muscular Dystrophy, Agents for; Anti-Hepatitis C Virus Drugs
DOM_SIM_243	Tranilast	Launched-1982	IL-10 Production Enhancers	Antiallergic Ophthalmic Agents; Drugs for Allergic Rhinitis; Asthma Therapy; Restenosis Treatment of; Uricosurics; Multiple Sclerosis, Agents for; Atopic Dermatitis, Agents for; Antiarthritic Drugs; Rheumatoid Arthritis, Treatment of; Urologic Drugs; Dermatologic Drugs; Antiglaucoma Agents
DOM_SIM_244	Glutamine dipeptide	Launched		Immunomodulators; Treatment of Mucositis; Treatment of Nutritional Disorders; Cytoprotectants
DOM_SIM_245	Balofloxacin dihydrate	Phase III	DNA Gyrase (Bacterial) Inhibitors	Antibacterial Drugs
DOM_SIM_246	4-Allylguaiacol	Clinical	MAO-A Inhibitors	Oncolytic Drugs; Antifungal Agents; Vasodilators
DOM_SIM_247	Cyproterone acetate	Launched-1973	Androgen Receptor Antagonists	Prostate Cancer Therapy; Treatment of Male Sexual Dysfunction; Hirsutism Therapy; Acne Therapy
DOM_SIM_248	Depomedroxyprogesterone acetate	Launched-1958	Progesterone Receptor Agonists	Prostate Cancer Therapy; Hormone Replacement Therapy; Female Contraceptives; Treatment of Menorrhagia; Oncolytic Drugs; Breast Cancer Therapy; Female Infertility, Agents for; Female Reproductive System Cancer Therapy; Endometriosis Therapy; Renal Cancer Therapy; Gynecological Disorders, Treatment of
DOM_SIM_249	Cordycepic acid	Launched		Chronic Obstructive Pulmonary Diseases (COPD), Treatment of; Treatment of Renal Diseases; Cystic Fibrosis, Treatment of ; Medical Diagnosis; Antiglaucoma Agents; Cerebrovascular Diseases, Treatment of
DOM_SIM_250	Provitamin A	Launched	Antioxidants	Oncolytic Drugs
DOM_SIM_251	Zolmitriptan	Launched-1997	5-HT1B Receptor Agonists	Acute Attacks of Migraine, Treatment of; Antimigraine Drugs; Analgesic Drugs; Lesions of the Spinal Cord and Related Structures, Treatment of
DOM_SIM_252	Indole-3-carbinol	Phase II	Aryl Hydrocarbon Receptor (AhR) Agonists	Chemopreventive Agents; Immunostimulants
DOM_SIM_253	5-Methoxypsoralen	Launched		Anti-HIV Agents; Chemopreventive Agents; Oncolytic Drugs; Antipsoriatics; Dermatologic Drugs
DOM_SIM_254	PK-11195	Clinical	Pregnane X Receptor (PXR) Agonists	Pharmacological Tools
DOM_SIM_255	Orbifloxacin	Launched-1994	DNA Gyrase (Bacterial) Inhibitors	Antibacterial Drugs
DOM_SIM_256	Cortisone acetate	Launched		Endocrine Disorders (Not Specified); Antiallergy/Antiasthmatic Drugs; Antiarthritic Drugs; Dermatologic Drugs; Respiratory Disorders (Not Specified)
DOM_SIM_257	Estradiol cypionate	Launched	Estrogen Receptor (ER) Agonists	Treatment of Postmenopausal Syndrome
DOM_SIM_258	Terameprocol	Phase I	Tat Inhibitors	Anti-Influenza Virus Drugs; Neurologic Cancer Therapy; Premalignant Conditions Therapy; Anti-Herpes Simplex Virus Drugs; Leukemia Therapy; Anti-Papilloma Virus Drugs; Head and Neck Cancer Therapy; Microbicides; Treatment of Autoimmune Diseases
DOM_SIM_259	Cinnarizine	Launched-1959	Histamine H1 Receptor Antagonists	Migraine, Prophylactic Treatment of; Treatment of Intermittent Claudication; Nausea and Vomiting, Treatment of; Raynaud's Phenomenon, Treatment for
DOM_SIM_260	Diindolylmethane	Phase II	Androgen Receptor Antagonists	Prostate Cancer Therapy; Premalignant Conditions Therapy; Cervical Cancer Therapy; Chemopreventive Agents; Immunostimulants
DOM_SIM_261	Licarbazepine	Phase III	Voltage-Gated Sodium Channel Blockers	Bipolar Disorder, Treatment of; Antiepileptic Drugs
DOM_SIM_262	D-(+)-Pinitol	Launched	gamma-Secretase Inhibitors	Alzheimer's Dementia, Treatment of ; Metabolic Disorders (Not Specified); Type 2 Diabetes, Agents for
DOM_SIM_263	2,4-Dihydroxypyrimidine-5-carboxylic acid			
DOM_SIM_264	Ibuprofen	Launched-1969	Prostaglandin G/H Synthase 2 (PTGS2; COX-2) Inhibitors	Non-Opioid Analgesics; Antimigraine Drugs; Osteoarthritis, Treatment of; Ankylosing Spondylitis, Treatment of; Rheumatoid Arthritis, Treatment of; Antiarthritic Drugs; Treatment of Tuberculosis
DOM_SIM_265	Baclofen	Launched-1971	GABA(B) Receptor Agonists	Treatment of Alcohol Dependency; Neurologic Drugs (Miscellaneous); Gastroesophageal Reflux Disease, Agents for; Antispastic Drugs; Neuropathy, Treatment of ; Treatment of Eating Disorders; Liver Cancer Therapy
DOM_SIM_266	Flumazenil	Launched-1987	GABA(A) BZ Site Receptor Antagonists	Sleep Disorders, Treatment of; Antagonists to Benzodiazepines
DOM_SIM_267	Curcumin	Not Applicable	CCND1 Expression Inhibitors	Myelodysplastic Syndrome Therapy; Multiple Myeloma Therapy; Prostate Cancer Therapy; Antimalarials; Premalignant Conditions Therapy; Cystic Fibrosis, Treatment of ; Treatment of Mucositis; Breast Cancer Therapy; Chemopreventive Agents; Antidepressants; Pancreatic Cancer Therapy; Alzheimer's Dementia, Treatment of ; Antiarthritic Drugs; Antibacterial Drugs; Colorectal Cancer Therapy; Antipsoriatics; Ocular Genetic Disorders, Treatment of
DOM_SIM_268	Oxipurinol	Clinical	Xanthine Oxidase Inhibitors	Renal and Urinary System Genetic Disorders, Treatment of ; Uricosurics; Heart Failure Therapy
DOM_SIM_269	fmoc-l-leucine	Phase II	Antiinflammatory Drugs	
DOM_SIM_270	1,2-Dihydrospirorenone	Launched-2019	Mineralocorticoid Receptor (MR) Antagonists	Hormone Replacement Therapy; Oral Contraceptives; Premenstrual Syndrome, Treatment of; Acne Therapy
DOM_SIM_271	Psoralen	Clinical		
DOM_SIM_272	Puerarin (Kakonein)		Large Conductance K(Ca) 1.1 (BK, maxi K+) Channel Activators	
DOM_SIM_273	Mycophenolate sodium	Launched-2003	Inosine 5'-Monophosphate Dehydrogenase (IMPDH) Inhibitors	Treatment of Transplant Rejection; Immunosuppressants; Dry Eye Syndrome, Treatment for; Sjogren's Syndrome, Agents for; Antipsoriatics; Systemic Lupus Erythematosus, Agents for; Treatment of Autoimmune Diseases
DOM_SIM_274	5-Azacitidine	Launched-2004	DNA Methyltransferase (DNMT) Inhibitors	Multiple Myeloma Therapy; Myelodysplastic Syndrome Therapy; Respiratory/Thoracic Cancer Therapy; Sarcoma Therapy; Prostate Cancer Therapy; Lymphocytic Leukemia Therapy; Immunomodulators; Non-Small Cell Lung Cancer Therapy; Leukemia Therapy; Melanoma Therapy; Brain Cancer Therapy; Breast Cancer Therapy; Oncolytic Drugs; Ovarian Cancer Therapy; Pancreatic Cancer Therapy; Digestive/Gastrointestinal Cancer Therapy; Colorectal Cancer Therapy; Myeloid Leukemia Therapy; Non-Hodgkin's Lymphoma Therapy; Hematopoiesis Disorders Therapy; Head and Neck Cancer Therapy; Solid Tumors Therapy
DOM_SIM_275	Thiothixene	Launched-1965		Antipsychotic Drugs
DOM_SIM_276	L-Methionine	Clinical	Calcium Channels (Voltage-Gated) alpha2/delta Subunit Ligands	Inflammation, Treatment of; Treatment of Hot Flushes; Antidepressants; Ophthalmic Drugs
DOM_SIM_277	Ethenzamide	Launched		Non-Opioid Analgesics; Antiarthritic Drugs; Antipyretics
DOM_SIM_278	Ferulic acid	Clinical	Antioxidants	Ultraviolet Light Absorbers; Antipruritics; Antiarthritic Drugs; Lipoprotein Disorders, Treatment of ; Alzheimer's Dementia, Treatment of
DOM_SIM_279	BW 58C			
DOM_SIM_280	Noradrenaline	Launched	alpha-Adrenoceptor Agonists	Attention Deficit Hyperactivity Disorder (ADHD), Treatment of; Septic Shock, Treatment of ; Hypotension, Treatment of; Antidepressants; Radioprotectants/Radiomitigators; Antiarrhythmic Drugs
DOM_SIM_281	5-Fluoro-2'-deoxycytidine	Phase II	DNA Methyltransferase (DNMT) Inhibitors	Myelodysplastic Syndrome Therapy; Myeloid Leukemia Therapy; Solid Tumors Therapy
DOM_SIM_282	Podofilox	Launched-1985	Potassium Channel Subfamily K Member 18 (TRESK; KCNK18) Blockers	Genital Warts, Treatment for
DOM_SIM_283	ectoine-zwitterion			
DOM_SIM_284	Terbinafine hydrochloride	Launched-1991	Squalene Monooxygenase (Fungal) Inhibitors	Antifungal Agents
DOM_SIM_285	Uridine	Phase II		Bipolar Disorder, Treatment of; Neurodegenerative Diseases, Treatment of; Anxiolytics; Antiepileptic Drugs
DOM_SIM_286	Galunisertib	Phase II	TGF-beta Receptor Type-1 (TGFBR1; ALK5; SKR4; TbetaR-I) Inhibitors	Myelodysplastic Syndrome Therapy; Prostate Cancer Therapy; Neurologic Cancer Therapy; Breast Cancer Therapy; Pancreatic Cancer Therapy; Female Reproductive System Cancer Therapy; Colorectal Cancer Therapy; Glioblastoma Multiforme Therapy; Liver Cancer Therapy; Solid Tumors Therapy
DOM_SIM_287	Ipriflavone	Launched-1988		Treatment of Osteoporosis
DOM_SIM_288	Narcosine	Launched-1963	Microtubule Destabilizers (Tubulin Polymerization Inhibitors)	Prostate Cancer Therapy; Multiple Myeloma Therapy; Neurodegenerative Diseases, Treatment of; Oncolytic Drugs; Fibrosis, Treatment of; Antitussives; Amyotrophic Lateral Sclerosis, Agents for; Non-Hodgkin's Lymphoma Therapy
DOM_SIM_289	Rosmarinic acid	Phase II	Antioxidants	Immunomodulators; Antiallergy/Antiasthmatic Drugs; Cognition Disorders, Treatment of; Acute Respiratory Distress Syndrome (ARDS), Agents for; Oncolytic Drugs; Antidepressants
DOM_SIM_290	Cinalukast	Phase II	Leukotriene CysLT1 (LTD4) Receptor Antagonists	Antiallergy/Antiasthmatic Drugs
DOM_SIM_291	Carbocysteine	Launched	Antioxidants	Chronic Obstructive Pulmonary Diseases (COPD), Treatment of
DOM_SIM_292	17-Hydroxyprogesterone caproate	Launched	Progesterone Receptor Agonists	Treatment of Preterm Labor; Disorders of Sexual Function and Reproduction, Treatment of; Female Reproductive System Cancer Therapy; Gynecological Disorders, Treatment of
DOM_SIM_293	Safranal	Clinical		Antiepileptic Drugs; Antitussives
DOM_SIM_294	Amifampridine	Registered-2019		Neurologic Drugs (Miscellaneous)
DOM_SIM_295	Pyridoxal phosphate	Phase II		Cardioprotective Agents; Tardive Dyskinesia, Treatment of; Metabolic and Nutritional Genetic Disorders, Treatment of ; Neurological Genetic Disorders, Treatment of ; Therapy of Inborn Errors of Metabolism; Hypertension, Treatment of; Stroke, Treatment of; Lipoprotein Disorders, Treatment of
DOM_SIM_296	3'-Deoxyadenosine	Phase I/II	Apoptosis Inducers	Lymphocytic Leukemia Therapy; Leukemia Therapy
DOM_SIM_297	Quinine hemisulfate	Launched	Gap Junction delta-2 Protein (GJD2; Cx36) Blockers	Antimalarials; Smooth Muscle Relaxants
DOM_SIM_298	Laurocapram	Clinical		Absorption Promoters
DOM_SIM_299	(-)-Epicatechin	Clinical	5-Lipoxygenase Inhibitors	Chemopreventive Agents; Lipoprotein Disorders, Treatment of ; Alzheimer's Dementia, Treatment of ; Antidiabetic Drugs
DOM_SIM_300	54359408			
DOM_SIM_301	Felbamate	Launched-1993	GABA(A) Receptor Modulators	Bipolar Disorder, Treatment of; Neurologic Drugs (Miscellaneous); Antiepileptic Drugs
DOM_SIM_302	D-Serine	Phase III	NMDA Glycine-Site Receptor Agonists	Psychiatric Disorders (Not Specified); Antiparkinsonian Drugs; Posttraumatic Stress Disorder (PTSD), Treatment of; Analgesic Enhancers
DOM_SIM_303	Phloretin	Clinical	VCAM1 (CD106; INCAM-100) Expression Inhibitors	Ultraviolet Light Absorbers; Antiplatelet Therapy; Hepatoprotectants
DOM_SIM_304	Ritodrine hydrochloride	Launched	beta2-Adrenoceptor Agonists	Treatment of Preterm Labor; Smooth Muscle Relaxants
DOM_SIM_305	N-2-Mercaptopropionyl-glycine	Launched	Antioxidants	Hemorrhagic Stroke, Treatment of; Metabolic Disorders (Not Specified); Liver and Biliary Tract Disorders, Treatment of
DOM_SIM_306	Ancitabine hydrochloride	Launched-1975		
DOM_SIM_307	Glycerol triheptanoate	Pre-Registered		Huntington's Disease, Treatment of; Metabolic and Nutritional Genetic Disorders, Treatment of ; Therapy of Inborn Errors of Metabolism; Neuromuscular Genetic Disorders, Treatment of; Metabolic Disorders (Not Specified); Amyotrophic Lateral Sclerosis, Agents for
DOM_SIM_308	Lactobionic acid	Launched	Matrix Metalloproteinase Inhibitors	Dermatologic Drugs
DOM_SIM_309	17beta-Estradiol	Launched-1988		Treatment of Postmenopausal Syndrome ; Restenosis Treatment of; Hormone Replacement Therapy; Wound-Healing Agents; Treatment of Hot Flushes; Treatment of Osteoporosis; Alzheimer's Dementia, Treatment of ; Antidepressants
DOM_SIM_310	Axitinib	Launched-2012	VEGFR-3 (FLT4) Inhibitors	Respiratory/Thoracic Cancer Therapy; Prostate Cancer Therapy; Treatment of Female Sexual Dysfunction; Endocrine Cancer Therapy; Non-Small Cell Lung Cancer Therapy; Neurological Genetic Disorders, Treatment of ; Melanoma Therapy; Gastric Cancer Therapy; Bladder Cancer Therapy ; Breast Cancer Therapy; Pancreatic Cancer Therapy; Cancer of Unspecified Body Location/System; Renal Cancer Therapy; Myeloid Leukemia Therapy; Colorectal Cancer Therapy; Glioblastoma Multiforme Therapy; Liver Cancer Therapy; Head and Neck Cancer Therapy
DOM_SIM_311	Dactolisib	Phase I/II	mTOR Complex 1 (mTORC1) Inhibitors	Prostate Cancer Therapy; Antiparkinsonian Drugs; Leukemia Therapy; Bladder Cancer Therapy ; Breast Cancer Therapy; Brain Cancer Therapy; Immunostimulants; Cancer of Unspecified Body Location/System; Pancreatic Cancer Therapy; Renal Cancer Therapy
DOM_SIM_312	Afatinib	Launched-2013	EGFR (HER1; erbB1) Inhibitors	Bone Cancer Therapy; Treatment of Female Sexual Dysfunction; Prostate Cancer Therapy; Non-Small Cell Lung Cancer Therapy; Neurologic Cancer Therapy; Gastric Cancer Therapy; Breast Cancer Therapy; Pancreatic Cancer Therapy; Digestive/Gastrointestinal Cancer Therapy; Female Reproductive System Cancer Therapy; Genitourinary Cancer Therapy; Glioblastoma Multiforme Therapy; Colorectal Cancer Therapy; Head and Neck Cancer Therapy; Solid Tumors Therapy
DOM_SIM_313	Bosutinib	Launched-2012	Src Kinase Family Inhibitors	Treatment of Renal Diseases; Non-Small Cell Lung Cancer Therapy; Leukemia Therapy; Cognition Disorders, Treatment of; Breast Cancer Therapy; Ischemic Stroke, Treatment of; Pancreatic Cancer Therapy; Myeloid Leukemia Therapy; Colorectal Cancer Therapy; Glioblastoma Multiforme Therapy
DOM_SIM_314	Cediranib maleate	Phase II	VEGFR-3 (FLT4) Inhibitors	Prostate Cancer Therapy; Small Cell Lung Cancer Therapy; Respiratory/Thoracic Cancer Therapy; Sarcoma Therapy; Myelodysplastic Syndrome Therapy; Non-Small Cell Lung Cancer Therapy; Endocrine Cancer Therapy; Lymphoma Therapy; Leukemia Therapy; Melanoma Therapy; Gastric Cancer Therapy; Ovarian Cancer Therapy; Breast Cancer Therapy; Digestive/Gastrointestinal Cancer Therapy; Myeloid Leukemia Therapy; Colorectal Cancer Therapy; Renal Cancer Therapy; Glioblastoma Multiforme Therapy; Solid Tumors Therapy; Liver Cancer Therapy; Head and Neck Cancer Therapy; Cancer Associated Disorders, Treatment of
DOM_SIM_315	Lenalidomide	Launched-2005	Protein Cereblon (CRBN) Inhibitors	Multiple Myeloma Therapy; Prostate Cancer Therapy; Myelodysplastic Syndrome Therapy; Lymphocytic Leukemia Therapy; Psychiatric Disorders (Not Specified); Non-Small Cell Lung Cancer Therapy; Endocrine Cancer Therapy; Lymphoma Therapy; Leukemia Therapy; Neurologic Cancer Therapy; Analgesic Drugs; Melanoma Therapy; Neuropathy, Treatment of ; Amyloidosis, Treatment of; Bladder Cancer Therapy ; Oncolytic Drugs; Pancreatic Cancer Therapy; Treatment of Other Autoimmune Disorders; Digestive/Gastrointestinal Cancer Therapy; Female Reproductive System Cancer Therapy; Renal Cancer Therapy; Glioblastoma Multiforme Therapy; Myeloid Leukemia Therapy; Hematological Cancer Therapy; Non-Hodgkin's Lymphoma Therapy; Treatment of AIDS-Associated Disorders; Liver Cancer Therapy; Hematopoiesis Disorders Therapy
DOM_SIM_316	Panobinostat lactate	Launched-2015	Histone Deacetylase (HDAC) Inhibitors	Respiratory/Thoracic Cancer Therapy; Multiple Myeloma Therapy; Myelodysplastic Syndrome Therapy; Bone Cancer Therapy; Prostate Cancer Therapy; Small Cell Lung Cancer Therapy; Sarcoma Therapy; Endocrine Cancer Therapy; Lymphoma Therapy; Non-Small Cell Lung Cancer Therapy; Leukemia Therapy; Anti-HIV Agents; Neurologic Cancer Therapy; Immunosuppressants; Gastric Cancer Therapy; Melanoma Therapy; Breast Cancer Therapy; Pancreatic Cancer Therapy; Myeloid Leukemia Therapy; Renal Cancer Therapy; Colorectal Cancer Therapy; Non-Hodgkin's Lymphoma Therapy; Hematopoiesis Disorders Therapy; Head and Neck Cancer Therapy; Liver Cancer Therapy
DOM_SIM_317	Vandetanib	Launched-2011	Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret (RET; CDHF12; PTC) Inhibitors	Prostate Cancer Therapy; Respiratory/Thoracic Cancer Therapy; Neurological Genetic Disorders, Treatment of ; Endocrine Cancer Therapy; Non-Small Cell Lung Cancer Therapy; Neurologic Cancer Therapy; Bladder Cancer Therapy ; Breast Cancer Therapy; Digestive/Gastrointestinal Cancer Therapy; Female Reproductive System Cancer Therapy; Pancreatic Cancer Therapy; Colorectal Cancer Therapy; Genitourinary Cancer Therapy; Renal Cancer Therapy; Glioblastoma Multiforme Therapy; Liver Cancer Therapy; Cancer Associated Disorders, Treatment of; Head and Neck Cancer Therapy
DOM_SIM_318	Elesclomol	Phase III	Heat Shock Protein 70 (Hsp70) Inducers	Sarcoma Therapy; Melanoma Therapy; Female Reproductive System Cancer Therapy; Myeloid Leukemia Therapy; Antineoplastic Enhancing Agents
DOM_SIM_319	Olaparib	Launched-2014	Poly(ADP-ribose) Polymerase 1 (PARP-1; ARTD1) Inhibitors	Small Cell Lung Cancer Therapy; Prostate Cancer Therapy; Sarcoma Therapy; Non-Small Cell Lung Cancer Therapy; Astrocytoma Therapy; Melanoma Therapy; Gastric Cancer Therapy; Ovarian Cancer Therapy; Breast Cancer Therapy; Bladder Cancer Therapy ; Pancreatic Cancer Therapy; Female Reproductive System Cancer Therapy; Cancer of Unspecified Body Location/System; Colorectal Cancer Therapy; Head and Neck Cancer Therapy; Pulmonary Hypertension, Treatment of; Non-Hodgkin's Lymphoma Therapy; Hematopoiesis Disorders Therapy
DOM_SIM_320	Pictilisib	Phase I	Phosphatidylinositol 3-Kinase (PI3K) Inhibitors	Non-Small Cell Lung Cancer Therapy; Breast Cancer Therapy; Non-Hodgkin's Lymphoma Therapy; Solid Tumors Therapy
DOM_SIM_321	Vismodegib	Launched-2012	P-Glycoprotein (MDR-1; ABCB1) Inhibitors	Interstitial Lung Diseases, Treatment of; Immunomodulators; Small Cell Lung Cancer Therapy; Prostate Cancer Therapy; Sarcoma Therapy; Multiple Myeloma Therapy; Myelodysplastic Syndrome Therapy; Basal Cell Carcinoma Therapy; Neurologic Cancer Therapy; Gastric Cancer Therapy; Oncolytic Drugs; Ovarian Cancer Therapy; Breast Cancer Therapy; Brain Cancer Therapy; Pancreatic Cancer Therapy; Colorectal Cancer Therapy; Glioblastoma Multiforme Therapy; Myeloid Leukemia Therapy; Hematopoiesis Disorders Therapy
DOM_SIM_322	Belinostat	Launched-2014	Histone Deacetylase 2 (HDAC2) Inhibitors	Respiratory/Thoracic Cancer Therapy; Small Cell Lung Cancer Therapy; Multiple Myeloma Therapy; Myelodysplastic Syndrome Therapy; Sarcoma Therapy; Non-Small Cell Lung Cancer Therapy; Bladder Cancer Therapy ; Ovarian Cancer Therapy; Cancer of Unspecified Body Location/System; Colorectal Cancer Therapy; Myeloid Leukemia Therapy; Non-Hodgkin's Lymphoma Therapy; Liver Cancer Therapy
DOM_SIM_323	Iniparib	Discontinued	Poly(ADP-ribose) Polymerase 1 (PARP-1; ARTD1) Inhibitors	Small Cell Lung Cancer Therapy; Non-Small Cell Lung Cancer Therapy; Neurologic Cancer Therapy; Ovarian Cancer Therapy; Breast Cancer Therapy; Female Reproductive System Cancer Therapy; Antineoplastic Enhancing Agents
DOM_SIM_324	Abexinostat	Phase III	RAD51 Expression Inhibitors	Sarcoma Therapy; Lymphoma Therapy; Breast Cancer Therapy; Renal Cancer Therapy; Myeloid Leukemia Therapy; Non-Hodgkin's Lymphoma Therapy; Solid Tumors Therapy
DOM_SIM_325	Dacinostat	Discontinued	Histone Deacetylase (HDAC) Inhibitors	Solid Tumors Therapy
DOM_SIM_326	BI 2536	Phase II	Bromodomain-Containing Protein 4 (Brd4, HUNK1) Inhibitors	Prostate Cancer Therapy; Small Cell Lung Cancer Therapy; Non-Small Cell Lung Cancer Therapy; Pancreatic Cancer Therapy; Myeloid Leukemia Therapy; Non-Hodgkin's Lymphoma Therapy; Solid Tumors Therapy
DOM_SIM_327	Cabozantinib S-malate	Launched-2013	Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret (RET; CDHF12; PTC) Inhibitors	Sarcoma Therapy; Small Cell Lung Cancer Therapy; Prostate Cancer Therapy; Multiple Myeloma Therapy; Non-Small Cell Lung Cancer Therapy; Endocrine Cancer Therapy; Neurological Genetic Disorders, Treatment of ; Melanoma Therapy; Skin Cancer Therapy; Oncolytic Drugs; Ovarian Cancer Therapy; Breast Cancer Therapy; Bladder Cancer Therapy ; Female Reproductive System Cancer Therapy; Digestive/Gastrointestinal Cancer Therapy; Pancreatic Cancer Therapy; Renal Cancer Therapy; Myeloid Leukemia Therapy; Colorectal Cancer Therapy; Osteosarcoma Therapy; Glioblastoma Multiforme Therapy; Liver Cancer Therapy; Head and Neck Cancer Therapy; Solid Tumors Therapy
DOM_SIM_328	Mocetinostat dihydrobromide	Phase II	Histone Deacetylase 1 (HDAC1) Inhibitors	Sarcoma Therapy; Lymphocytic Leukemia Therapy; Myelodysplastic Syndrome Therapy; Lymphoma Therapy; Non-Small Cell Lung Cancer Therapy; Bladder Cancer Therapy ; Oncolytic Drugs; Pancreatic Cancer Therapy; Myeloid Leukemia Therapy; Non-Hodgkin's Lymphoma Therapy; Squamous Cell Carcinoma Therapy
DOM_SIM_329	Ivacaftor	Launched-2012	Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Potentiators	Chronic Obstructive Pulmonary Diseases (COPD), Treatment of; Treatment of Upper Respiratory Tract Disorders; Cystic Fibrosis, Treatment of
DOM_SIM_330	PD-98059		NADPH Oxidase (NOX) Inhibitors	
DOM_SIM_331	Raltitrexed	Launched-1996	Thymidylate Synthase Inhibitors	Leukemia Therapy; Gastric Cancer Therapy; Oncolytic Drugs; Colorectal Cancer Therapy; Solid Tumors Therapy
DOM_SIM_332	Dutasteride	Launched-2003	Steroid 5alpha-Reductase Type 1 Inhibitors	Prostate Cancer Therapy; Benign Prostatic Hyperplasia Therapy; Contraceptives; Hair Growth Stimulants; Neuromuscular Genetic Disorders, Treatment of; Chemopreventive Agents; Premenstrual Syndrome, Treatment of
DOM_SIM_333	Tivozanib	Launched-2017	VEGFR-3 (FLT4) Inhibitors	Sarcoma Therapy; Age-Related Macular Degeneration, Treatment of; Non-Small Cell Lung Cancer Therapy; Astrocytoma Therapy; Oncolytic Drugs; Breast Cancer Therapy; Ovarian Cancer Therapy; Female Reproductive System Cancer Therapy; Renal Cancer Therapy; Colorectal Cancer Therapy; Liver Cancer Therapy
DOM_SIM_334	Nelarabine	Launched-2006	Antimetabolites	Lymphocytic Leukemia Therapy; Lymphoma Therapy
DOM_SIM_335	Clofarabine	Launched-2005	DNA Polymerase Inhibitors	Lymphocytic Leukemia Therapy; Multiple Myeloma Therapy; Myelodysplastic Syndrome Therapy; Leukemia Therapy; Multiple Sclerosis, Agents for; Oncolytic Drugs; Antipsoriatics; Hematological Cancer Therapy; Myeloid Leukemia Therapy; Solid Tumors Therapy; Hematopoiesis Disorders Therapy; Non-Hodgkin's Lymphoma Therapy
DOM_SIM_336	Enzalutamide	Launched-2012	Selective Androgen Receptor Modulators (SARM)	Prostate Cancer Therapy; Ovarian Cancer Therapy; Oncolytic Drugs; Breast Cancer Therapy; Bladder Cancer Therapy ; Pancreatic Cancer Therapy; Female Reproductive System Cancer Therapy; Renal Cancer Therapy; Liver Cancer Therapy; Head and Neck Cancer Therapy
DOM_SIM_337	Dienogest	Launched-2008	Progesterone Receptor Agonists	Treatment of Dysmenorrhea; Hormone Replacement Therapy; Disorders of Sexual Function and Reproduction, Treatment of; Endometriosis Therapy; Gynecological Disorders, Treatment of
DOM_SIM_338	Ramelteon	Launched-2005	Melatonin MT2 Receptor Agonists	Bipolar Disorder, Treatment of; Antimigraine Drugs; Sleep Disorders, Treatment of
DOM_SIM_339	Vemurafenib	Launched-2011	Raf kinase B Inhibitors	Multiple Myeloma Therapy; Endocrine Cancer Therapy; Non-Small Cell Lung Cancer Therapy; Leukemia Therapy; Melanoma Therapy; Brain Cancer Therapy; Colorectal Cancer Therapy; Hematopoiesis Disorders Therapy
DOM_SIM_340	Adapalene	Launched-1995	Retinoid Acid Receptor beta (RARB) Agonists	Multiple Sclerosis, Agents for; Acne Therapy
DOM_SIM_341	Zoledronate	Launched-2000	Farnesyl Pyrophosphate Synthase Inhibitors	Bone Cancer Therapy; Treatment of Paget's Disease; Prostate Cancer Therapy; Bone Resorption Inhibitors; Premalignant Conditions Therapy; Neurologic Cancer Therapy; Neuropathic Pain, Treatment of; Osteoarthritis, Treatment of; Breast Cancer Therapy; Oncolytic Drugs; Sickle Cell Anemia, Agents for; Treatment of Osteoporosis; Rheumatoid Arthritis, Treatment of; Treatment of Hypercalcemia; Solid Tumors Therapy; Bone Diseases, Treatment of
DOM_SIM_342	(R)-Etodolac	Phase II	Apoptosis Inducers	Lymphocytic Leukemia Therapy
DOM_SIM_343	TG-100115	Phase I/II	Phosphatidylinositol 3-Kinase (PI3K) Inhibitors	Asthma Therapy; Oncolytic Drugs; Acute Myocardial Infarction, Treatment of
DOM_SIM_344	(-)-Epothilone B	Phase I/II	Microtubule Stabilizers (Tubulin Depolymerization Inhibitors)	Prostate Cancer Therapy; Non-Small Cell Lung Cancer Therapy; Breast Cancer Therapy; Oncolytic Drugs; Ovarian Cancer Therapy; Female Reproductive System Cancer Therapy; Colorectal Cancer Therapy; Liver Cancer Therapy; Solid Tumors Therapy
DOM_SIM_345	Ruxolitinib phosphate	Launched-2011	Jak2 Inhibitors	Lymphocytic Leukemia Therapy; Prostate Cancer Therapy; Multiple Myeloma Therapy; Non-Small Cell Lung Cancer Therapy; Lymphoma Therapy; Immunosuppressants; Anti-HIV Agents; Lung Cancer Therapy; Premalignant Conditions Therapy; Leukemia Therapy; Treatment of Cachexia; Atopic Dermatitis, Agents for; Breast Cancer Therapy; Rheumatoid Arthritis, Treatment of; Pancreatic Cancer Therapy; Hematological Cancer Therapy; Antipsoriatics; Myeloid Leukemia Therapy; Colorectal Cancer Therapy; Dermatologic Drugs; Hematologic Agents (Miscellaneous); Treatment of Autoimmune Diseases; Hematopoiesis Disorders Therapy; Non-Hodgkin's Lymphoma Therapy; Antithrombocythemic; Head and Neck Cancer Therapy
DOM_SIM_346	Tenofovir	Clinical	Reverse Transcriptase/Ribonuclease H (HIV-1) Inhibitors	Anti-Hepatitis B Virus Drugs; Anti-HIV Agents; Microbicides
DOM_SIM_347	Tipifarnib	Phase II	Farnesyltransferase (geranylgeranyl pyrophosphate synthase) Inhibitors	Prostate Cancer Therapy; Lymphocytic Leukemia Therapy; Myelodysplastic Syndrome Therapy; Multiple Myeloma Therapy; Non-Small Cell Lung Cancer Therapy; Leukemia Therapy; Neurologic Cancer Therapy; Lung Cancer Therapy; Multisystem Genetic Disorders, Treatment of ; Melanoma Therapy; Breast Cancer Therapy; Bladder Cancer Therapy ; Brain Cancer Therapy; Pancreatic Cancer Therapy; Glioblastoma Multiforme Therapy; Myeloid Leukemia Therapy; Genitourinary Cancer Therapy; Anti-Hepatitis D Virus Drugs; Solid Tumors Therapy; Head and Neck Cancer Therapy; Non-Hodgkin's Lymphoma Therapy
DOM_SIM_348	Neflamapimod	Phase II	MAPK p38 Inhibitors	Myelodysplastic Syndrome Therapy; Huntington's Disease, Treatment of; Cognition Disorders, Treatment of; Stroke, Treatment of; Rheumatoid Arthritis, Treatment of; Alzheimer's Dementia, Treatment of
DOM_SIM_349	GW 501516	Phase II	Insulin Sensitizers	Atherosclerosis Therapy; Lipoprotein Disorders, Treatment of ; Metabolic Disorders (Not Specified); Type 2 Diabetes, Agents for
DOM_SIM_350	Pimasertib hydrochloride	Phase II	Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2; MEK2) Inhibitors	Melanoma Therapy; Ovarian Cancer Therapy; Oncolytic Drugs; Pancreatic Cancer Therapy; Colorectal Cancer Therapy; Hematological Cancer Therapy; Myeloid Leukemia Therapy; Solid Tumors Therapy
DOM_SIM_351	AEE788	Phase I/II	EGFR (HER1; erbB1) Inhibitors	Colorectal Cancer Therapy; Glioblastoma Multiforme Therapy; Solid Tumors Therapy
DOM_SIM_352	Mycophenolate mofetil	Launched-1995	Hydroxycarboxylic Acid Receptor 2 (HCAR2; NIACR1; GPR109A) Agonists	Interstitial Lung Diseases, Treatment of; Treatment of Renal Diseases; Myelodysplastic Syndrome Therapy; Scleroderma, Agents for; Treatment of Transplant Rejection; Anti-HIV Agents; Immunosuppressants; Atopic Dermatitis, Agents for; Antiinfectives (Not Specified); Myasthenia Gravis, Agents for; Systemic Lupus Erythematosus, Agents for; Antipsoriatics; Dermatologic Drugs; Treatment of Autoimmune Diseases; Nephritis, Agents for
DOM_SIM_353	Alprostadil	Launched-1979		Treatment of Female Sexual Dysfunction; Hypotension, Treatment of; Antiplatelet Therapy; Agents for Viral Hepatitis; Atherosclerosis Therapy; Wound-Healing Agents; Treatment of Erectile Dysfunction; Raynaud's Phenomenon, Treatment for ; Medical Diagnosis; Cardiovascular Diseases (Not Specified); Treatment of Peripheral Obstructive Vascular Disease; Peripheral Arterial Disease, Treatment of
DOM_SIM_354	Pracinostat hydrochloride	Phase III	Histone Deacetylase 2 (HDAC2) Inhibitors	Myelodysplastic Syndrome Therapy; Prostate Cancer Therapy; Sarcoma Therapy; Antimalarials; Leukemia Therapy; Oncolytic Drugs; Myeloid Leukemia Therapy; Solid Tumors Therapy; Hematopoiesis Disorders Therapy
DOM_SIM_355	Cidofovir	Launched-1996	DNA Polymerase Inhibitors	Anti-Herpes Simplex Virus Drugs; Anti-Papilloma Virus Drugs; Anti-Cytomegalovirus Drugs; Antiviral Drugs
DOM_SIM_356	Adavosertib	Phase II	Wee2-Like Protein Kinase 2 (Wee2) Inhibitors	Small Cell Lung Cancer Therapy; Myelodysplastic Syndrome Therapy; Non-Small Cell Lung Cancer Therapy; Cervical Cancer Therapy; Gastric Cancer Therapy; Ovarian Cancer Therapy; Breast Cancer Therapy; Female Reproductive System Cancer Therapy; Myeloid Leukemia Therapy; Glioblastoma Multiforme Therapy; Colorectal Cancer Therapy; Solid Tumors Therapy; Head and Neck Cancer Therapy
DOM_SIM_357	Pimobendan	Launched-1994	Calcium Sensitizers	Heart Failure Therapy
DOM_SIM_358	BMS 777607	Phase I	Tyrosine-Protein Kinase Mer (MERTK) Inhibitors	Treatment of Osteoporosis; Solid Tumors Therapy; Cancer Associated Disorders, Treatment of
DOM_SIM_359	Lumacaftor	Phase III	Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) (DeltaF508 Mutant) Correctors	Cystic Fibrosis, Treatment of
DOM_SIM_360	Tazarotene	Launched-1996	Ornithine Decarboxylase (ODC1) Inhibitors	Neurological Genetic Disorders, Treatment of ; Basal Cell Carcinoma Therapy; Oncolytic Drugs; Antipsoriatics; Dermatologic Drugs; Acne Therapy
DOM_SIM_361	RO4929097	Phase II	Drugs Acting on Notch Receptors	Prostate Cancer Therapy; Sarcoma Therapy; Non-Small Cell Lung Cancer Therapy; Melanoma Therapy; Oncolytic Drugs; Breast Cancer Therapy; Alzheimer's Dementia, Treatment of ; Pancreatic Cancer Therapy; Glioblastoma Multiforme Therapy; Renal Cancer Therapy; Colorectal Cancer Therapy; Solid Tumors Therapy
DOM_SIM_362	Apixaban	Launched-2011	Coagulation Factor Xa Inhibitors	Stroke, Treatment of; Anticoagulants; Angina pectoris, Treatment of; Antiarrhythmic Drugs
DOM_SIM_363	Erteberel	Phase II	Estrogen Receptor (ER) beta Agonists	Benign Prostatic Hyperplasia Therapy; Antipsychotic Drugs
DOM_SIM_364	Cefdinir	Launched-1991	Penicillin-Binding Protein (PBP) (Bacterial) Inhibitors	Antibiotics; Antibacterial Drugs
DOM_SIM_365	Emtricitabine	Launched-2003	Reverse Transcriptase/Ribonuclease H (HIV-1) Inhibitors	Anti-Hepatitis B Virus Drugs; Neurological Genetic Disorders, Treatment of ; Anti-HIV Agents
DOM_SIM_366	Deferasirox	Launched-2005	Chelating Agents	Antianemics; Myelodysplastic Syndrome Therapy; Antagonists to Metals; Treatment of Osteoporosis
DOM_SIM_367	Chlorprothixene	Launched-1959	Dopamine D2 Receptor (DRD2) Antagonists	Antipsychotic Drugs
DOM_SIM_368	Risedronate sodium	Launched-1998	Farnesyl Pyrophosphate Synthase Inhibitors	Treatment of Paget's Disease; Treatment of Osteoporosis; Bone Diseases, Treatment of
DOM_SIM_369	Lacidipine	Launched-1991	Calcium Channel Blockers	Hypertension, Treatment of; Antileishmanials
DOM_SIM_370	54749203		HIV Integrase Inhibitors	
DOM_SIM_371	Epalrestat	Launched-1992	Aldose Reductase Inhibitors	Neurodegenerative Diseases, Treatment of; Treatment of Diabetic Complications; Breast Cancer Therapy; Type 2 Diabetes, Agents for; Diabetic Neuropathy, Agents for
DOM_SIM_372	Ambrisentan	Launched-2007	Endothelin-1 Receptor (EDNRA, ETAR) Antagonists	Interstitial Lung Diseases, Treatment of; Scleroderma, Agents for; Hypertension, Treatment of; Heart Failure Therapy; Pulmonary Hypertension, Treatment of; Renal Failure, Agents for
DOM_SIM_373	Imidapril hydrochloride	Launched-1993	Angiotensin-I Converting Enzyme (ACE) Inhibitors	Hypertension, Treatment of; Diabetic Nephropathy, Agents for
DOM_SIM_374	Blonanserin	Launched-2008	5-HT2A Receptor Antagonists	Antipsychotic Drugs
DOM_SIM_375	Licofelone	Phase III	Prostaglandin G/H Synthase 2 (PTGS2; COX-2) Inhibitors	Non-Opioid Analgesics; Osteoarthritis, Treatment of; Inflammation, Treatment of; Antiarthritic Drugs
DOM_SIM_376	Fudosteine	Launched-2001		
DOM_SIM_377	GSK1292263	Phase II	Glucose-Dependent Insulinotropic Receptor (GDIR; GPR119) Agonists	Lipoprotein Disorders, Treatment of ; Type 2 Diabetes, Agents for
DOM_SIM_378	Sonidegib phosphate	Launched-2015	Smoothened (Smo) Receptor Antagonists	Multiple Myeloma Therapy; Prostate Cancer Therapy; Small Cell Lung Cancer Therapy; Basal Cell Carcinoma Therapy; Leukemia Therapy; Gastric Cancer Therapy; Brain Cancer Therapy; Oncolytic Drugs; Ovarian Cancer Therapy; Breast Cancer Therapy; Pancreatic Cancer Therapy; Female Reproductive System Cancer Therapy; Glioblastoma Multiforme Therapy; Hematological Cancer Therapy; Treatment of Autoimmune Diseases; Liver Cancer Therapy; Agents for Liver Cirrhosis; Hematopoiesis Disorders Therapy
DOM_SIM_379	KW 2449	Discontinued	Tyrosine-Protein Kinase ABL1 (ABL) Inhibitors	Oncolytic Drugs
DOM_SIM_380	Mubritinib	Discontinued	HER2 (erbB2) Inhibitors	Breast Cancer Therapy
DOM_SIM_381	N-(4-carboxyphenyl)-alpha-D-mannopyranosylamine			
DOM_SIM_382	Pikamilone	Phase II		Anxiolytics; Cognition Disorders, Treatment of
DOM_SIM_383	Indibulin	Phase I/II	Microtubule Destabilizers (Tubulin Polymerization Inhibitors)	Oncolytic Drugs; Breast Cancer Therapy; Solid Tumors Therapy
DOM_SIM_384	REN-1189	Discontinued	MAPK p38 Inhibitors	AIDS Dementia, Treatment of; Antiparkinsonian Drugs; Neuropathic Pain, Treatment of; Alzheimer's Dementia, Treatment of
DOM_SIM_385	Mequitazine	Launched	Histamine H1 Receptor Antagonists	Drugs for Allergic Rhinitis; Urticaria, Treatment for; Antipruritics; Antiallergy/Antiasthmatic Drugs; Allergic Skin Disorders, Treatment for
DOM_SIM_386	13771288			
DOM_SIM_387	Pivagabine	Phase I/II	CRF Receptor Antagonists	Anxiolytics; Antidepressants
DOM_SIM_388	Verubulin hydrochloride	Phase I/II	Microtubule Destabilizers (Tubulin Polymerization Inhibitors)	Non-Small Cell Lung Cancer Therapy; Melanoma Therapy; Oncolytic Drugs; Brain Cancer Therapy
DOM_SIM_389	Benfotiamine	Launched	Paraptosis Inducers	Neurologic Drugs (Miscellaneous); Diabetic Retinopathy, Agents for; Treatment of Diabetic Complications; Alzheimer's Dementia, Treatment of ; Diabetic Nephropathy, Agents for
DOM_SIM_390	Aminoguanidine	Phase III	Inducible Nitric Oxide Synthase (NOS-2) Inhibitors	Diabetic Retinopathy, Agents for; Diabetic Nephropathy, Agents for
DOM_SIM_391	Triprolidine hydrochloride	Launched-1953	Histamine H1 Receptor Antagonists	Drugs for Allergic Rhinitis; Allergic Skin Disorders, Treatment for
DOM_SIM_392	Piricapiron	Phase II	5-HT1A Receptor Agonists	
DOM_SIM_393	Bonaphthone	Clinical		Antiviral Drugs
DOM_SIM_394	Olopatadine hydrochloride	Launched-1997	Histamine H1 Receptor Antagonists	Antiallergic Ophthalmic Agents; Drugs for Allergic Rhinitis; Allergy, Treatment of; Urticaria, Treatment for; Eczema, Treatment of; Antipruritics; Atopic Dermatitis, Agents for; Antiallergy/Antiasthmatic Drugs; Dermatologic Drugs; Antipsoriatics; Allergic Skin Disorders, Treatment for
DOM_SIM_395	Esaprazole hydrochloride	Phase III		Antiulcer Drugs
DOM_SIM_396	Timofibrate	Clinical		Lipoprotein Disorders, Treatment of ; Treatment of Disorders of Purine and Pyrimidine Metabolism
DOM_SIM_397	Flumexadol	Clinical		Non-Opioid Analgesics
DOM_SIM_398	SNAP-37889	Phase I/II	Galanin GAL3 Receptor Antagonists	
DOM_SIM_399	Letosteine	Launched		
DOM_SIM_400	Succinylcholine chloride	Launched-1951		Neuromuscular Blockers
DOM_SIM_401	Tiracizine hydrochloride	Launched-1990		Antiarrhythmic Drugs
DOM_SIM_402	Brolitene	Launched		Antispastic Drugs and Drugs for Muscle Spasms; Inflammation, Treatment of; Muscle Spasms, Drugs for
DOM_SIM_403	Isbufylline	Phase II		
DOM_SIM_404	Befol	Clinical		
DOM_SIM_405	Ecabamide	Phase III		Antiulcer Drugs; Prokinetic Agents; Anti-Helicobacter Pylori Agents
DOM_SIM_406	OCO-1112	Phase II		Lipoprotein Disorders, Treatment of
DOM_SIM_407	Nebracetam	Phase III	Muscarinic M1 Receptor Agonists	Cognition Disorders, Treatment of
DOM_SIM_408	Metoprine	Clinical		Leukemia Therapy
DOM_SIM_409	Methazolamide	Launched	Carbonic Anhydrase Type II Inhibitors	Antiepileptic Drugs; Oncolytic Drugs; Antiglaucoma Agents; Type 2 Diabetes, Agents for
DOM_SIM_410	Etacizin	Launched-1989		Antiarrhythmic Drugs
DOM_SIM_411	(+)-R-Pramipexole dihydrochloride	Phase II	Antioxidants	Treatment of Upper Respiratory Tract Disorders; Asthma Therapy; Amyotrophic Lateral Sclerosis, Agents for; Alzheimer's Dementia, Treatment of ; Hematopoiesis Disorders Therapy
DOM_SIM_412	Tetrindol	Registered-1992	MAO-A Inhibitors	Cognition Disorders, Treatment of; Antidepressants
DOM_SIM_413	Difloxacin hydrochloride	Phase II	DNA Gyrase (Bacterial) Inhibitors	Antibacterial Drugs
DOM_SIM_414	4-Aminopyridine	Launched-2010	Potassium Channel Blockers	Sleep Apnea, Treatment of; Antiparkinsonian Drugs; Neurologic Drugs (Miscellaneous); Neurological Genetic Disorders, Treatment of ; Multiple Sclerosis, Agents for; Ischemic Stroke, Treatment of; Lesions of the Spinal Cord and Related Structures, Treatment of
DOM_SIM_415	Ornithine phenylacetate	Phase II	NF-kappaB (NFKB) Modulators	Liver and Biliary Tract Disorders, Treatment of; Metabolic Disorders (Not Specified); Agents for Liver Cirrhosis
DOM_SIM_416	Fasudil hydrochloride	Launched-1995	Calcium Sensitizers	Antiparkinsonian Drugs; Neurologic Drugs (Miscellaneous); Stroke, Treatment of; Amyotrophic Lateral Sclerosis, Agents for; Angina pectoris, Treatment of; Vasodilators; Cerebrovascular Diseases, Treatment of; Pulmonary Hypertension, Treatment of
DOM_SIM_417	Chlormethiazole edisylate	Launched-1957	MAPK p38 Inhibitors	Stroke, Treatment of; Sedative/Hypnotics; Antiepileptic Drugs
DOM_SIM_418	Vortioxetine hydrobromide	Launched-2013	5-HT1A Receptor Agonists	Attention Deficit Hyperactivity Disorder (ADHD), Treatment of; Cognition Disorders, Treatment of; Antidepressants; Treatment of Eating Disorders; Generalized Anxiety Disorder (GAD), Treatment of
DOM_SIM_419	Emoxipin hydrochloride	Phase III	Lipid Peroxidation Inhibitors	
DOM_SIM_420	Nibentan	Phase II	Potassium Channel Blockers	Antiarrhythmic Drugs
DOM_SIM_421	Levobetaxolol hydrochloride	Launched-2000	beta-Adrenoceptor Antagonists	Antiglaucoma Agents
DOM_SIM_422	Edetic acid	Clinical	Protein Kinase C (PKC) Inhibitors	Hypertension, Treatment of; Oncolytic Drugs
DOM_SIM_423	Pyrantel pamoate	Launched		Treatment of Helminthic Diseases
DOM_SIM_424	Ethimizol	Phase III		Respiratory Stimulants; Cognition Disorders, Treatment of; Antiallergy/Antiasthmatic Drugs
DOM_SIM_425	Tenilsetam	Discontinued	AGE Inhibitors (Maillard's Reaction Inhibitors)	Diabetic Retinopathy, Agents for; Cognition Disorders, Treatment of
DOM_SIM_426	Fadrozole	Launched	Aromatase Inhibitors	Oncolytic Drugs
DOM_SIM_427	Oseltamivir phosphate	Launched-1999	Neuraminidase (Sialidase) (Influenza Virus) Inhibitors	Anti-Influenza Virus Drugs; Antithrombocytopenic; Anti-Coronavirus (CoV) Drugs
DOM_SIM_428	Talniflumate	Launched-1982	Mucin Production Inhibitors	Antiarthritic Drugs; Correction of Mucus Abnormalities; Mucolytics
DOM_SIM_429	Antiepilepsirine	Phase III		Antiepileptic Drugs
DOM_SIM_430	Tetrabenazine	Launched	Vesicular Monoamine Transporter 2 (VMAT2) Inhibitors	Huntington's Disease, Treatment of; Tardive Dyskinesia, Treatment of; Extrapyramidal Disorders, Treatment of; Tourette's Syndrome, Treatment of
DOM_SIM_431	Nuclomedone	Phase III		
DOM_SIM_432	Danofloxacin	Phase II	Glutathione Peroxidase Inhibitors	Antibacterial Drugs
DOM_SIM_433	Bromantan	Clinical		Treatment of Renal Diseases; Anxiolytics; CNS Stimulants; Fibrosis, Treatment of; Liver and Biliary Tract Disorders, Treatment of; Immunostimulants
DOM_SIM_434	Fenoldopam mesilate	Launched-1998	Dopamine D1 Receptor (DRD1) Agonists	Hypertension, Treatment of; Renal Failure, Agents for
DOM_SIM_435	Benflumetol	Launched-1987		
DOM_SIM_436	Xilobam	Clinical		Muscle Spasms, Drugs for
DOM_SIM_437	MK-571 	Phase III	Leukotriene CysLT1 (LTD4) Receptor Antagonists	Antiallergy/Antiasthmatic Drugs
DOM_SIM_438	Remacemide hydrochloride	Discontinued	NMDA Receptor Antagonists	Huntington's Disease, Treatment of; Autism, Treatment of; Antiepileptic Drugs
DOM_SIM_439	Proxodolol	Phase II	beta-Adrenoceptor Antagonists	Hypertension, Treatment of; Angina pectoris, Treatment of; Antiglaucoma Agents
DOM_SIM_440	Tasuldine	Phase III		
DOM_SIM_441	Doxapram hydrochloride	Launched	Potassium Channel Subfamily K Member 3 (TASK1; KCNK3) Blockers	Chronic Obstructive Pulmonary Diseases (COPD), Treatment of; Nausea and Vomiting, Treatment of; Respiratory Disorders (Not Specified)
DOM_SIM_442	Tromaril	Clinical		Inflammation, Treatment of
DOM_SIM_443	Etofilline clofibrate	Launched		Lipoprotein Disorders, Treatment of
DOM_SIM_444	Ethambutol	Launched	Cell Wall Biosynthesis Inhibitors	Antimycobacterial Agents; Treatment of Tuberculosis
DOM_SIM_445	Indobufen	Launched-1984		Antiplatelet Therapy; Anticoagulants
DOM_SIM_446	Fingolimod hydrochloride	Launched-2010	Sphingosine 1-Phosphate Receptor 1 (S1PR1; EDG1) Agonists	Asthma Therapy; Neurological Genetic Disorders, Treatment of ; Treatment of Transplant Rejection; Immunosuppressants; Multiple Sclerosis, Agents for; Neuropathy, Treatment of ; Antipsychotic Drugs; Amyotrophic Lateral Sclerosis, Agents for
DOM_SIM_447	Nimustine hydrochloride	Launched	Apoptosis Inducers	Neurologic Cancer Therapy; Lung Cancer Therapy; Colorectal Cancer Therapy
DOM_SIM_448	Lidamidine hydrochloride	Launched-1984		Antidiarrheal Agents
DOM_SIM_449	Amiridine	Discontinued	Acetylcholinesterase (AChE) Inhibitors	Alzheimer's Dementia, Treatment of
DOM_SIM_450	(+)-Sotalol	Phase III	beta-Adrenoceptor Antagonists	Antiarrhythmic Drugs
DOM_SIM_451	Oseltamivir carboxylate	Clinical	Neuraminidase (Sialidase) (Influenza Virus) Inhibitors	Anti-Influenza Virus Drugs
DOM_SIM_452	(L)-Lobeline sulfate	Phase III	mu-Opioid Receptor Antagonists	Smoking Cessation, Aid to
DOM_SIM_453	Valrocemide	Discontinued		Bipolar Disorder, Treatment of; Neurologic Drugs (Miscellaneous); Neuropathic Pain, Treatment of; Antiepileptic Drugs
DOM_SIM_454	Cetilistat	Registered-2013	Hormone-Sensitive Lipase (LIPE; HSL) Inhibitors	Antiobesity Drugs
DOM_SIM_455	trans-9,trans-11-Conjugated linoleic acid			
DOM_SIM_456	Fenofibric acid	Clinical		Lipoprotein Disorders, Treatment of
DOM_SIM_457	Fludarabine phosphate	Launched-1991	Purine Antagonists	Lymphocytic Leukemia Therapy; Restenosis Treatment of; Neurologic Cancer Therapy; Multisystem Genetic Disorders, Treatment of ; Melanoma Therapy; Non-Hodgkin's Lymphoma Therapy
DOM_SIM_458	Rhein	Clinical	ADP-Ribosyl Cyclase/Cyclic ADP-Ribose Hydrolase 1 (CD38) Inhibitors	Oncolytic Drugs; Antiarthritic Drugs; Diabetic Nephropathy, Agents for
DOM_SIM_459	Exalamide	Launched-1980		Antifungal Agents
DOM_SIM_460	Pleconaril		Viral Entry Inhibitors	Antiviral Drugs
DOM_SIM_461	Triclabendazole	Launched	DNA Methyltransferase 1 (DNMT1) Inhibitors	Treatment of Helminthic Diseases
DOM_SIM_462	5-Fluorodeoxyuridine	Launched-1987	Thymidylate Synthase Inhibitors	Oncolytic Drugs; Antibacterial Drugs
DOM_SIM_463	(+/-)-Equol	Phase II	Apoptosis Inducers	Inflammatory Bowel Disease, Agents for; Actinic Keratoses, Agents for; Smooth Muscle Relaxants; Chemopreventive Agents; Oncolytic Drugs; Treatment of Osteoporosis; Radioprotectants/Radiomitigators; Dermatologic Drugs
DOM_SIM_464	Ampalex	Discontinued	AMPA Receptor Positive Allosteric Modulators	Mental Retardation, Treatment of; Attention Deficit Hyperactivity Disorder (ADHD), Treatment of; Antinarcoleptic Drugs; Autism, Treatment of; Antipsychotic Drugs; Cognition Disorders, Treatment of; Alzheimer's Dementia, Treatment of
DOM_SIM_465	Eflornithine hydrochloride	Launched-1991	Ornithine Decarboxylase (ODC1) Inhibitors	Antitrypanosomals; Premalignant Conditions Therapy; Astrocytoma Therapy; Neurologic Cancer Therapy; Gastric Cancer Therapy; Skin Cancer Therapy; Bladder Cancer Therapy ; Chemopreventive Agents; Pancreatic Cancer Therapy; Excessive Facial Hair in Women, Treatment of; Adenomatous Polyposis Therapy; Esophageal Diseases, Treatment of
DOM_SIM_466	Tolamolol	Clinical	beta-Adrenoceptor Antagonists	Angina pectoris, Treatment of; Antiarrhythmic Drugs
DOM_SIM_467	Retinal	Launched		Dermatologic Drugs
DOM_SIM_468	Parecoxib sodium	Launched-2002	Prostaglandin G/H Synthase 2 (PTGS2; COX-2) Inhibitors	Analgesic Drugs
DOM_SIM_469	Cefprozil monohydrate	Launched-1992		
DOM_SIM_470	RN-1734	Clinical	TRPV4 Antagonists	Pharmacological Tools
DOM_SIM_471	Sorafenib	Launched-2005	Raf kinase B Inhibitors	Sarcoma Therapy; Myelodysplastic Syndrome Therapy; Prostate Cancer Therapy; Small Cell Lung Cancer Therapy; Multiple Myeloma Therapy; Respiratory/Thoracic Cancer Therapy; Endocrine Cancer Therapy; Non-Small Cell Lung Cancer Therapy; Neurologic Drugs (Miscellaneous); Neurologic Cancer Therapy; Cervical Cancer Therapy; Lung Cancer Therapy; Hypertension, Treatment of; Melanoma Therapy; Breast Cancer Therapy; Bladder Cancer Therapy ; Ovarian Cancer Therapy; Oncolytic Drugs; Digestive/Gastrointestinal Cancer Therapy; Female Reproductive System Cancer Therapy; Pancreatic Cancer Therapy; Colorectal Cancer Therapy; Hematological Cancer Therapy; Genitourinary Cancer Therapy; Renal Cancer Therapy; Myeloid Leukemia Therapy; Glioblastoma Multiforme Therapy; Pulmonary Hypertension, Treatment of; Liver Cancer Therapy; Non-Hodgkin's Lymphoma Therapy; Solid Tumors Therapy; Head and Neck Cancer Therapy
DOM_SIM_472	Pibenzimol	Phase II		Oncolytic Drugs
DOM_SIM_473	SEP-227900	Discontinued	D-Amino Acid Oxidase (DAAO) Inhibitors	Neuropathic Pain, Treatment of; Cognition Disorders, Treatment of; Alzheimer's Dementia, Treatment of
DOM_SIM_474	Pemirolast	Launched-1991	Mediator Release Inhibitors	
DOM_SIM_475	DL-Thiaproline	Launched		Hepatoprotectants; Oncolytic Drugs
DOM_SIM_476	Cannabidiol	Launched-2018	Cannabinoid Receptor Agonists	Neurological Genetic Disorders, Treatment of ; Anxiolytics; Neurologic Drugs (Miscellaneous); Inflammatory Bowel Disease, Agents for; Diabetic Retinopathy, Agents for; Basal Cell Carcinoma Therapy; Neurologic Cancer Therapy; Analgesic Drugs; Autism, Treatment of; Multisystem Genetic Disorders, Treatment of ; Neuropathy, Treatment of ; Stroke, Treatment of; Antipsychotic Drugs; Atopic Dermatitis, Agents for; Neuropathic Pain, Treatment of; Antiepileptic Drugs; Oncolytic Drugs; Treatment of Substance Dependency; Metabolic Disorders (Not Specified); Liver and Biliary Tract Disorders, Treatment of; Lipoprotein Disorders, Treatment of ; Rheumatoid Arthritis, Treatment of; Glioblastoma Multiforme Therapy; Treatment of Autoimmune Diseases; Ischemia, Treatment of; Acne Therapy; Squamous Cell Carcinoma Therapy
DOM_SIM_477	Bifendate	Launched		Anti-Hepatitis B Virus Drugs; Hepatoprotectants
DOM_SIM_478	Toloxatone	Launched-1984	MAO-A Inhibitors	
DOM_SIM_479	Ivabradine hydrochloride	Launched-2005	HCN [I(f)] Blockers	Neurologic Drugs (Miscellaneous); Angina pectoris, Treatment of; Heart Failure Therapy; Cardiovascular Diseases (Not Specified); Urologic Drugs
DOM_SIM_480	Bromodeoxyuridine	Phase III	Antimetabolites	Bladder Cancer Therapy ; Head and Neck Cancer Therapy
DOM_SIM_481	Etonogestrel	Launched	Progesterone Receptor Agonists	Benign Prostatic Hyperplasia Therapy; Contraceptives; Female Contraceptives
DOM_SIM_482	Amsacrine	Launched-1982	DNA-Intercalating Drugs	Oncolytic Drugs
DOM_SIM_483	Artemether	Launched-1987		Antimalarials; Solid Tumors Therapy
DOM_SIM_484	Org-26576	Phase II	AMPA Receptor Modulators	Attention Deficit Hyperactivity Disorder (ADHD), Treatment of; Antidepressants
DOM_SIM_485	Perillyl alcohol	Phase I/II	Apoptosis Inducers	Prostate Cancer Therapy; Actinic Keratoses, Agents for; Neurologic Cancer Therapy; Breast Cancer Therapy; Ovarian Cancer Therapy; Chemopreventive Agents; Pancreatic Cancer Therapy; Colorectal Cancer Therapy
DOM_SIM_486	Dexrazoxane hydrochloride	Launched-1992	Chelating Agents	Cardioprotectants; Chemoprotective Agents; Antineoplastic Enhancing Agents
DOM_SIM_487	Acitretin	Launched-1985		Antipsoriatics; Allergic Skin Disorders, Treatment for
DOM_SIM_488	Razoxane	Launched	DNA Topoisomerase II Inhibitors	Oncolytic Drugs; Chemoprotective Agents
DOM_SIM_489	(S)-Tofisopam	Phase II	GABA(A) BZ Site Receptor Agonists	Treatment of Postmenopausal Syndrome ; Treatment of Gout; Anxiolytics; Antiepileptic Drugs; Treatment of Disorders of Purine and Pyrimidine Metabolism
DOM_SIM_490	Marbofloxacin	Launched	DNA Gyrase (Bacterial) Inhibitors	Antibacterial Drugs
DOM_SIM_491	Diclondazolic acid	Launched-1987	Phosphotransferase (HK) (Trypanosoma brucei) Inhibitors	Benign Prostatic Hyperplasia Therapy; Oncolytic Drugs
DOM_SIM_492	Methsuximide	Launched-1954		Antiepileptic Drugs
DOM_SIM_493	Atenolol	Launched-1975	beta1-Adrenoceptor Antagonists	Hypertension, Treatment of; Acute Myocardial Infarction, Treatment of; Angina pectoris, Treatment of; Bone, Muscles and Connective Tissue Genetic Disorders, Treatment of; Heart Failure Therapy; Antiarrhythmic Drugs
DOM_SIM_494	Erythritol	Phase II		Stroke, Treatment of
DOM_SIM_495	Alanosine	Phase II		Non-Small Cell Lung Cancer Therapy; Brain Cancer Therapy
DOM_SIM_496	Cromakalim	Phase III	K(ATP) Channel Activators	Urinary Incontinence Therapy; Antiulcer Drugs; Antiallergy/Antiasthmatic Drugs; Hypertension, Treatment of; Bronchodilators; Vasodilators; Irritable Bowel Syndrome, Agents for
DOM_SIM_497	Valnoctamide	Launched		Anxiolytics; Antiepileptic Drugs
DOM_SIM_498	trofinetide	Phase III	NMDA Receptor Ligands	Psychiatric Disorders (Not Specified); Neurologic Drugs (Miscellaneous); Cognition Disorders, Treatment of; Antiepileptic Drugs; Antidepressants
DOM_SIM_499	Zileuton	Launched-2005	5-Lipoxygenase Inhibitors	Respiratory/Thoracic Cancer Therapy; Interstitial Lung Diseases, Treatment of; Chronic Obstructive Pulmonary Diseases (COPD), Treatment of; Antiallergy/Antiasthmatic Drugs; Myeloid Leukemia Therapy; Acne Therapy
DOM_SIM_500	Phylloquinone	Launched-1944		Hemostatics; Neurologic Drugs (Miscellaneous)
DOM_SIM_501	Bexarotene	Launched-2000	Extracellular-Regulated Kinase (ERK) Inhibitors	Antiparkinsonian Drugs; Cushing's Syndrome, Agents for; Non-Small Cell Lung Cancer Therapy; Endocrine Cancer Therapy; Lung Cancer Therapy; Atopic Dermatitis, Agents for; Antipsychotic Drugs; Chemopreventive Agents; Breast Cancer Therapy; Alzheimer's Dementia, Treatment of ; Antipsoriatics; Renal Cancer Therapy; Dermatologic Drugs; Hematological Cancer Therapy; Non-Hodgkin's Lymphoma Therapy; Head and Neck Cancer Therapy
DOM_SIM_502	Proflavine	Clinical		
DOM_SIM_503	Metanicotine	Phase II	Nicotinic alpha4beta2 Receptor Agonists	Attention Deficit Hyperactivity Disorder (ADHD), Treatment of; Inflammatory Bowel Disease, Agents for; Cognition Disorders, Treatment of; Smoking Cessation, Aid to
DOM_SIM_504	N,N'-Diacetyl-L-cystine	Phase II		Immunomodulators; Atherosclerosis Therapy
DOM_SIM_505	Felbinac ethyl	Launched-1989		Antiarthritic Drugs
DOM_SIM_506	Etomidate	Launched-1977		General Anesthetics
DOM_SIM_507	17-Acetoxyprogesterone	Clinical	Steroid 5alpha-Reductase Inhibitors	Benign Prostatic Hyperplasia Therapy; Female Infertility, Agents for
DOM_SIM_508	Adefovir dipivoxil	Launched-2002	DNA Polymerase Inhibitors	Anti-Hepatitis B Virus Drugs; Anti-HIV Agents
DOM_SIM_509	Anabasine hydrochloride	Launched-1987	Nicotinic Receptor Agonists	Smoking Cessation, Aid to
DOM_SIM_510	Cantharidin	Launched	Protein Phosphatase 2A (PP-2A) Inhibitors	Anti-Papilloma Virus Drugs; Oncolytic Drugs; Pharmacological Tools; Antiviral Drugs; Dermatologic Drugs
DOM_SIM_511	Rufinamide	Launched-2007	Voltage-Gated Sodium Channel Blockers	Bipolar Disorder, Treatment of; Anxiolytics; Neuropathic Pain, Treatment of; Anesthetic Drugs; Antiepileptic Drugs; Generalized Anxiety Disorder (GAD), Treatment of
DOM_SIM_512	mCyd	Phase II	RNA-Directed RNA Polymerase (NS5B) (HCV) Inhibitors	Anti-Hepatitis C Virus Drugs
DOM_SIM_513	Enprofylline	Phase III	Adenosine A2B Receptor Antagonists	
DOM_SIM_514	IO-21	Phase II		Antiulcer Drugs
DOM_SIM_515	1,8-Cineole	Clinical	Acetylcholinesterase (AChE) Inhibitors	Inflammatory Bowel Disease, Agents for; Asthma Therapy
DOM_SIM_516	Stiripentol	Launched-2007	GABA Reuptake Inhibitors	Antiepileptic Drugs
DOM_SIM_517	Eliprodil	Phase III	NMDA Receptor Antagonists	Multiple Sclerosis, Agents for; Ischemic Stroke, Treatment of
DOM_SIM_518	Tamibarotene	Launched-2005	Neutrophil Elastase (Leukocyte Elastase) Release Inhibitors	Myelodysplastic Syndrome Therapy; Non-Small Cell Lung Cancer Therapy; Neurologic Drugs (Miscellaneous); Alzheimer's Dementia, Treatment of ; Ophthalmic Drugs; Myeloid Leukemia Therapy; Nephritis, Agents for; Liver Cancer Therapy; Solid Tumors Therapy
DOM_SIM_519	Pirfenidone	Launched-2008	Transforming Growth Factor beta Inhibitors	Interstitial Lung Diseases, Treatment of; Treatment of Renal Diseases; Neurologic Drugs (Miscellaneous); Therapy of Inborn Errors of Metabolism; Treatment of Transplant Rejection; Multiple Sclerosis, Agents for; Agents for Liver Fibrosis; Heart Failure Therapy; Diabetic Nephropathy, Agents for; Respiratory Disorders (Not Specified)
DOM_SIM_520	Loxiglumide	Discontinued	CCK1 (CCKA) Receptor Antagonists	Pancreatic Disorders, Treatment of
DOM_SIM_521	Alovudine	Phase II	Reverse Transcriptase/Ribonuclease H (HIV-1) Inhibitors	Anti-HIV Agents
DOM_SIM_522	Fesoterodine fumarate	Launched-2008	Muscarinic Receptor Antagonists	Urinary Incontinence Therapy; Lesions of the Spinal Cord and Related Structures, Treatment of
DOM_SIM_523	Bemesetron	Phase II	5-HT3 Receptor Antagonists	Antimigraine Drugs; Nausea and Vomiting, Treatment of
DOM_SIM_524	M-2000	Phase II	MMP-2 (Gelatinase A) Inhibitors	Immunomodulators; Multiple Sclerosis, Agents for; Breast Cancer Therapy; Chemopreventive Agents; Antiarthritic Drugs; Nephritis, Agents for
DOM_SIM_525	L-Dopa methyl ester hydrochloride	Launched-2000	Dopamine Precursors	Antiparkinsonian Drugs
DOM_SIM_526	Hypericin	Phase III	Protein Kinase C (PKC) Inhibitors	Anti-HIV Agents; Antipsoriatics; Antiviral Drugs; Glioblastoma Multiforme Therapy; Diagnosis of Cancer; Non-Hodgkin's Lymphoma Therapy
DOM_SIM_527	Lynestrenol	Launched	Progesterone Receptor Agonists	
DOM_SIM_528	6-Aminochrysene	Phase II		
DOM_SIM_529	Azamianserin	Launched-1994	5-HT2A Receptor Antagonists	Sleep Apnea, Treatment of; Fibromyalgia, Treatment of; Mood Disorders, Treatment of; Sleep Disorders, Treatment of; Antidepressants; Treatment of Substance Dependency; Treatment of Eating Disorders
DOM_SIM_530	Mebrofenin	Launched-1987		Medical Diagnosis
DOM_SIM_531	Cocositol	Phase II/III	beta-Amyloid (Abeta) Aggregation Inhibitors	Bipolar Disorder, Treatment of; Psychiatric Disorders (Not Specified); Neurological Genetic Disorders, Treatment of ; Alzheimer's Dementia, Treatment of
DOM_SIM_532	Antineoplaston AS2-5	Phase II		Prostate Cancer Therapy
DOM_SIM_533	Tempol-H	Phase II	Antioxidants	Age-Related Macular Degeneration, Treatment of; Diabetic Retinopathy, Agents for; Anticataract Agents
DOM_SIM_534	Uracil	Pre-Registered	Dihydropyrimidine Dehydrogenase Inhibitors	Disorders Associated with Cancer Therapy, Treatment of; Dermatologic Drugs
DOM_SIM_535	Dizocilpine	Phase II	NMDA Receptor Antagonists	Prion Diseases, Treatment of; Cognition Disorders, Treatment of; Stroke, Treatment of; Antiepileptic Drugs
DOM_SIM_536	Couroupitine B	Clinical	Cyclin-Dependent Kinase 1 (CDK1) Inhibitors	Myeloid Leukemia Therapy; Antipsoriatics
DOM_SIM_537	Parthenolide	Clinical	NF-kappaB (NFKB) Activation Inhibitors	Septic Shock, Treatment of ; Atherosclerosis Therapy; Oncolytic Drugs; Antileishmanials; Anti-Hepatitis C Virus Drugs
DOM_SIM_538	AR-42 (HDAC-42)	Phase I	Histone Deacetylase 2 (HDAC2) Inhibitors	Lymphocytic Leukemia Therapy; Multiple Myeloma Therapy; Sarcoma Therapy; Neurologic Drugs (Miscellaneous); Lymphoma Therapy; Neurologic Cancer Therapy; Treatment of Cachexia; Oncolytic Drugs; Myeloid Leukemia Therapy; Renal Cancer Therapy; Solid Tumors Therapy
DOM_SIM_539	Etofibrate	Launched	PPARalpha Agonists	Lipoprotein Disorders, Treatment of
DOM_SIM_540	Meldonium hydrate	Launched	gamma-Butyrobetaine Dioxygenase (BBOX; BBOX1) Inhibitors	Acute Myocardial Infarction, Treatment of; Angina pectoris, Treatment of
DOM_SIM_541	Mozavaptan hydrochloride	Launched-2006	Vasopressin (AVP) V2 Receptor Antagonists	Treatment of Renal Diseases; Heart Failure Therapy
DOM_SIM_542	Intepirdine	Discontinued	5-HT6 Receptor Antagonists	Antipsychotic Drugs; Cognition Disorders, Treatment of; Alzheimer's Dementia, Treatment of
DOM_SIM_543	Fedratinib hydrochloride	Launched-2019	FLT3 (FLK2/STK1) Inhibitors	Hematopoietic Agents; Hematological Cancer Therapy; Hematologic Agents (Miscellaneous); Solid Tumors Therapy
DOM_SIM_544	Silibinin	Phase II	Apoptosis Inhibitors	Immunomodulators; Hepatoprotectants; Oncolytic Drugs; Chemopreventive Agents; Antidiabetic Drugs; Anti-Hepatitis C Virus Drugs
DOM_SIM_545	Amygdalin	Clinical	Caspase 3 Activators	Oncolytic Drugs
DOM_SIM_546	Teriflunomide	Launched-2012	Dihydroorotate Dehydrogenase (DHODH) Inhibitors	Immunosuppressants; Disease-Modifying Anti-Rheumatic Drugs; Multiple Sclerosis, Agents for
DOM_SIM_547	Troxipide	Launched-1986		Antiulcer Drugs
DOM_SIM_548	Dapivirine	Pre-Registered	Reverse Transcriptase/Ribonuclease H (HIV-1) Inhibitors	Anti-HIV Agents; Microbicides
DOM_SIM_549	Prucalopride hydrochloride	Clinical	5-HT4 Receptor Agonists	Prokinetic Agents
DOM_SIM_550	Anacetrapib	Discontinued	Cholesteryl Ester Transfer Protein (CETP) Inhibitors	Atherosclerosis Therapy; Lipoprotein Disorders, Treatment of
DOM_SIM_551	Clinofibrate	Launched-1981		Lipoprotein Disorders, Treatment of
DOM_SIM_552	Josamycin	Launched		ntibiotics
DOM_SIM_553	(+)-Ursolic acid	Phase II	11-beta-Hydroxysteroid Dehydrogenase Type 1 (11beta-HSD1) Inhibitors	Antitrypanosomals; Anti-HIV Agents; Non-Opioid Analgesics; Cognition Disorders, Treatment of; Chemopreventive Agents; Oncolytic Drugs; Metabolic Disorders (Not Specified); Antiarthritic Drugs; Type 2 Diabetes, Agents for
DOM_SIM_554	Digitoxin	Launched		Cystic Fibrosis, Treatment of ; Heart Failure Therapy
DOM_SIM_555	beta-Sitosterol		Neutrophil Elastase (Leukocyte Elastase) Release Inhibitors	
DOM_SIM_556	Betulin	Clinical	ACAT 1 Inhibitors	Lipoprotein Disorders, Treatment of ; Antiviral Drugs
DOM_SIM_557	Simeprevir	Launched-2013	Serine Protease NS3/Non-Structural Protein 4A (NS3/NS4A) (HCV) Inhibitors	Anti-Hepatitis C Virus Drugs
DOM_SIM_558	Linagliptin	Launched-2011	Dipeptidyl Peptidase IV (CD26; DPP-IV; DP-IV) Inhibitors	Type 2 Diabetes, Agents for; Renal Failure, Agents for
DOM_SIM_559	Venetoclax	Launched-2016	Apoptosis Regulator Bcl-2 Inhibitors	Lymphocytic Leukemia Therapy; Multiple Myeloma Therapy; Myelodysplastic Syndrome Therapy; Prostate Cancer Therapy; Oncolytic Drugs; Breast Cancer Therapy; Amyloidosis, Treatment of; Myeloid Leukemia Therapy; Hematological Cancer Therapy; Systemic Lupus Erythematosus, Agents for; Non-Hodgkin's Lymphoma Therapy
DOM_SIM_560	KPT-9274	Phase I	Serine/Threonine-Protein Kinase PAK4 Inhibitors	Neurologic Cancer Therapy; Oncolytic Drugs; Non-Hodgkin's Lymphoma Therapy; Solid Tumors Therapy
DOM_SIM_561	Atazanavir sulfate	Launched-2003	HIV Protease Inhibitors	Type 1 Diabetes, Agents for; Anti-HIV Agents; Type 2 Diabetes, Agents for
DOM_SIM_562	Sertaconazole nitrate	Launched-1992	Tryptophan 2,3-Dioxygenase (TDO) Inhibitors	Antifungal Agents
DOM_SIM_563	20-O-beta-D-Glucopyranosyl-20	Phase I	NF-kappaB (NFKB) Activation Inhibitors	Oncolytic Drugs
DOM_SIM_564	N-tert-Butylisoquine	Discontinued		
DOM_SIM_565	Indinavir sulfate	Launched-1996	HIV Protease Inhibitors	Kaposi's Sarcoma Therapy; Anti-HIV Agents
DOM_SIM_566	Astemizole	Withdrawn-1999	Histamine H1 Receptor Antagonists	Drugs for Allergic Rhinitis; Antimalarials
DOM_SIM_567	Niclosamide	Launched	Quorum Sensing (Pseudomonas aeruginosa) Inhibitors	Atopic Dermatitis, Agents for; Oncolytic Drugs; Treatment of Helminthic Diseases; Rheumatoid Arthritis, Treatment of; Antibacterial Drugs; Antiviral Drugs
DOM_SIM_568	Rifapentin	Launched-1998	RNA Polymerase (Bacterial) Inhibitors	Antimycobacterial Agents; Treatment of Tuberculosis
DOM_SIM_569	AR-12	Phase I	Acetyl-Coenzyme A Synthetase (Fungal) Inhibitors	Oncolytic Drugs; Chemopreventive Agents; Antifungal Agents; Antiviral Drugs; Antibacterial Drugs
DOM_SIM_570	Paritaprevir	Phase III	Serine Protease NS3/Non-Structural Protein 4A (NS3/NS4A) (HCV) Inhibitors	Anti-Hepatitis C Virus Drugs
DOM_SIM_571	Ledipasvir	Phase III	Non-Structural Protein 5A (NS5A) (HCV) Inhibitors	Anti-Hepatitis C Virus Drugs
DOM_SIM_572	Gossypol	Phase I	Nuclear Receptor Coactivator 3 (NCoA-3; SRC-3) Inhibitors	Prostate Cancer Therapy; Bladder Cancer Therapy ; Male Contraceptives
DOM_SIM_573	Fenebrutinib	Phase II	Bruton's Tyrosine Kinase (BTK) Inhibitors	Lymphocytic Leukemia Therapy; Urticaria, Treatment for; Rheumatoid Arthritis, Treatment of; Systemic Lupus Erythematosus, Agents for; Non-Hodgkin's Lymphoma Therapy
DOM_SIM_574	Navitoclax	Phase III	Bcl-2-Like Protein 2 (Bcl-W; BCL2L2) Inhibitors	Small Cell Lung Cancer Therapy; Lymphocytic Leukemia Therapy; Prostate Cancer Therapy; Lymphoma Therapy; Osteoarthritis, Treatment of; Hematopoiesis Disorders Therapy; Liver Cancer Therapy; Solid Tumors Therapy; Antineoplastic Enhancing Agents
DOM_SIM_575	Olcegepant	Discontinued	Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonists	Antimigraine Drugs
DOM_SIM_576	BMS-599626	Phase I	EGFR (HER1; erbB1) Inhibitors	Neurologic Cancer Therapy; Oncolytic Drugs; Solid Tumors Therapy
DOM_SIM_577	Keoxifene hydrochloride	Launched-1998	Selective Estrogen Receptor Modulators (SERM)	Prostate Cancer Therapy; Treatment of Disorders of the Coronary Arteries and Atherosclerosis; Breast Cancer Therapy; Treatment of Osteoporosis; Rheumatoid Arthritis, Treatment of; Alzheimer's Dementia, Treatment of ; Hematologic Agents (Miscellaneous); Anti-Hepatitis C Virus Drugs
DOM_SIM_578	Grazoprevir hydrate	Launched-2016	Serine Protease NS3/Non-Structural Protein 4A (NS3/NS4A) (HCV) Inhibitors	Anti-Hepatitis C Virus Drugs
DOM_SIM_579	2alpha-hydroxyursolic acid	Clinical	11-beta-Hydroxysteroid Dehydrogenase Type 1 (11beta-HSD1) Inhibitors	Oncolytic Drugs; Type 2 Diabetes, Agents for
DOM_SIM_580	Ocaperidone	Phase II	5-HT2A Receptor Antagonists	Antipsychotic Drugs
DOM_SIM_581	Birinapant	Phase I/II	Inhibitor of Apoptosis Proteins (IAP) Inhibitors	Myelodysplastic Syndrome Therapy; Anti-Hepatitis B Virus Drugs; Lymphoma Therapy; Ovarian Cancer Therapy; Female Reproductive System Cancer Therapy; Colorectal Cancer Therapy; Myeloid Leukemia Therapy; Solid Tumors Therapy; Head and Neck Cancer Therapy
DOM_SIM_582	AMG 900	Phase I	Aurora kinase A (AURK1; ARK1) Inhibitors	Ovarian Cancer Therapy; Hematological Cancer Therapy; Solid Tumors Therapy
DOM_SIM_583	Rifaximin	Launched-1988	Pregnane X Receptor (PXR) Agonists	Antibiotics; Neurologic Drugs (Miscellaneous); Inflammatory Bowel Disease, Agents for; Antiulcer Drugs; Metabolic Disorders (Not Specified); Liver and Biliary Tract Disorders, Treatment of; Irritable Bowel Syndrome, Agents for; Respiratory Disorders (Not Specified); Acne Therapy
DOM_SIM_584	Succinobucol	Phase III	ERK1 Inhibitors	Restenosis Treatment of; Atherosclerosis Therapy; Type 2 Diabetes, Agents for
DOM_SIM_585	Ansamitocin P-3		Antimitotic Drugs	
DOM_SIM_586	Lixivaptan	Phase II	Vasopressin (AVP) V2 Receptor Antagonists	Diuretics; Renal and Urinary System Genetic Disorders, Treatment of ; Heart Failure Therapy
DOM_SIM_587	Tegobuvir	Phase II	RNA-Directed RNA Polymerase (NS5B) (HCV) Inhibitors	Anti-Hepatitis C Virus Drugs
DOM_SIM_588	Pranlukast hydrate	Launched-1995	Leukotriene CysLT1 (LTD4) Receptor Antagonists	Chronic Obstructive Pulmonary Diseases (COPD), Treatment of; Drugs for Allergic Rhinitis; Treatment of Upper Respiratory Tract Disorders; Asthma Therapy
DOM_SIM_589	Nanchangmycin		Viral Entry Inhibitors	
DOM_SIM_590	Posaconazole	Launched-2005	Lanosterol 14alpha-Demethylase (CYP51) (Fungal) Inhibitors	Antitrypanosomals; Antifungal Agents
DOM_SIM_591	Batefenterol succinate	Phase II	Muscarinic Receptor Antagonists	Chronic Obstructive Pulmonary Diseases (COPD), Treatment of; Asthma Therapy
DOM_SIM_592	PF-3758309	Discontinued	Serine/Threonine-Protein Kinase PAK4 Inhibitors	Solid Tumors Therapy
DOM_SIM_593	Quiflapon Sodium	Phase II	Leukotriene Synthesis Inhibitors	Inflammatory Bowel Disease, Agents for
DOM_SIM_594	Diclazuril	Phase III		Treatment of Protozoal Diseases
DOM_SIM_595	Chidamide	Launched-2015	Histone Deacetylase 11 (HDAC11) Inhibitors	Multiple Myeloma Therapy; Non-Small Cell Lung Cancer Therapy; Anti-HIV Agents; Melanoma Therapy; Breast Cancer Therapy; Oncolytic Drugs; Cancer of Unspecified Body Location/System; Myeloid Leukemia Therapy; Renal Cancer Therapy; Colorectal Cancer Therapy; Non-Hodgkin's Lymphoma Therapy; Solid Tumors Therapy
DOM_SIM_596	Daclatasvir dihydrochloride	Launched-2014	Non-Structural Protein 5A (NS5A) (HCV) Inhibitors	Anti-Hepatitis C Virus Drugs
DOM_SIM_597	GS-9851	Phase I	RNA-Directed RNA Polymerase (NS5B) (HCV) Inhibitors	Anti-Hepatitis C Virus Drugs
DOM_SIM_598	Telaprevir	Launched-2011	Serine Protease NS3/Non-Structural Protein 4A (NS3/NS4A) (HCV) Inhibitors	Anti-Hepatitis C Virus Drugs
DOM_SIM_599	Povan	Launched	Androgen Receptor Antagonists	Oncolytic Drugs; Gastrointestinal Genetic Disorders, Treatment of ; Treatment of Helminthic Diseases
DOM_SIM_600	Halofantrine hydrochloride	Launched-1988		
DOM_SIM_601	Maraviroc	Launched-2007	Chemokine CCR5 Receptor Antagonists	Anti-HIV Agents; Immunosuppressants; Stroke, Treatment of; Rheumatoid Arthritis, Treatment of; Colorectal Cancer Therapy; Microbicides
DOM_SIM_602	Vindesine	Launched-1979		Oncolytic Drugs
DOM_SIM_603	Sinefungin			
DOM_SIM_604	Clomiphene	Launched-1961		
DOM_SIM_605	Reparixin	Phase III	Chemokine CXCR1/CXCR2 (IL-8 Receptor) Receptor Antagonists	Treatment of Transplant Rejection; Acute Respiratory Distress Syndrome (ARDS), Agents for; Acute Myocardial Infarction, Treatment of; Breast Cancer Therapy; Antiarthritic Drugs
DOM_SIM_606	DF-2755A		Chemokine CXCR2 (IL-8 beta Receptor) Antagonists	
DOM_SIM_607	Ladarixin sodium	Phase II	Chemokine CXCR2 (IL-8 beta Receptor) Antagonists	Chronic Obstructive Pulmonary Diseases (COPD), Treatment of; Type 1 Diabetes, Agents for; Inflammatory Bowel Disease, Agents for; Melanoma Therapy; Antipsoriatics; Dermatologic Drugs